BACKGROUND Cyclins and cyclin-dependent kinases (CDKs) drive cell division. Of
particular importance to the cancer field are D-cyclins, which activate CDK4 and CDK6. In …

Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …

Lysine lactylation (Kla) is a recently discovered histone mark derived from metabolic lactate.
The NAD+‐dependent deacetylase SIRT3, which can also catalyze removal of the lactyl …

The epidermal growth factor receptor (EGFR) is one of most potent oncogenes that are
commonly altered in cancers. As a receptor tyrosine kinase, EGFR's kinase activity has been …

E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle
machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent …

Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor types and
represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins …

E-type cyclins E1 (CcnE1) and E2 (CcnE2) are regulatory subunits of cyclin-dependent
kinase 2 (Cdk2) and thought to control the transition of quiescent cells into the cell cycle …

Inhibitors of cyclin-dependent kinases CDK4 and CDK6 have been approved for treatment
of hormone receptor–positive breast cancers. In contrast, triple-negative breast cancers …

Background & Aims The CCNE1 locus, which encodes cyclin E1, is amplified in many types
of cancer cells and is activated in hepatocellular carcinomas (HCCs) from patients infected …

Abstract Background Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic
target in tubo‐ovarian high‐grade serous carcinoma (HGSC). Smaller studies have revealed …