[HTML][HTML] Implications of NQO1 in cancer therapy
ET Oh, HJ Park - BMB reports, 2015 - ncbi.nlm.nih.gov
Abstract NAD (P) H: quinone oxidoreductase (NQO1), an obligatory two-electron reductase,
is a ubiquitous cytosolic enzyme that catalyzes the reduction of quinone substrates. The …
is a ubiquitous cytosolic enzyme that catalyzes the reduction of quinone substrates. The …
The protective effect of natural compounds against rotenone‐induced neurotoxicity
Rotenone is a widely used organic pesticide; its serious side effect for off‐target species is
neurotoxicity. The primary mechanism of rotenone toxicity is inhibition of the mitochondrial …
neurotoxicity. The primary mechanism of rotenone toxicity is inhibition of the mitochondrial …
Lipophilicity, pharmacokinetic properties, and molecular docking study on SARS-CoV-2 target for betulin triazole derivatives with attached 1, 4-quinone
M Kadela-Tomanek, M Jastrzębska, K Marciniec… - Pharmaceutics, 2021 - mdpi.com
A key parameter in the design of new active compounds is lipophilicity, which influences the
solubility and permeability through membranes. Lipophilicity affects the pharmacodynamic …
solubility and permeability through membranes. Lipophilicity affects the pharmacodynamic …
The potential of Ginkgo biloba in the treatment of human diseases and the relationship to Nrf2–mediated antioxidant protection
Objectives This review summarises the current findings regarding the therapeutic effects of
GBE and its active ingredients in relation to the Nrf2 antioxidant cascade, to provide …
GBE and its active ingredients in relation to the Nrf2 antioxidant cascade, to provide …
The effects of in ovo feeding of selenized glucose on selenium concentration and antioxidant capacity of breast muscle in neonatal broilers
M Zhao, J Li, Q Shi, H Shan, L Liu, T Geng, L Yu… - … Trace Element Research, 2023 - Springer
This study aims to investigate the impacts of in ovo feeding (IOF) of selenized glucose
(SeGlu) on selenium (Se) level and antioxidant capacity of breast muscle in newborn …
(SeGlu) on selenium (Se) level and antioxidant capacity of breast muscle in newborn …
Association of Genetic Variations in NRF2, NQO1, HMOX1, and MT with Severity of Coronary Artery Disease and Related Risk Factors
I Sarutipaiboon, N Settasatian, N Komanasin… - Cardiovascular …, 2020 - Springer
NRF2 is a transcription factor which, during oxidative stress, activates transcription of its
target antioxidant genes. Polymorphisms in NRF2 and its target antioxidant genes: HMOX-1 …
target antioxidant genes. Polymorphisms in NRF2 and its target antioxidant genes: HMOX-1 …
Флавоноиды глазами фармаколога. Антиоксидантная и противовоспалительная активность
ЯФ Зверев - Обзоры по клинической фармакологии и …, 2017 - cyberleninka.ru
Обзор литературы посвящен рассмотрению механизмов антиоксидантного и
противовоспалительного действия флавоноидов. При обсуждении антиоксидантного …
противовоспалительного действия флавоноидов. При обсуждении антиоксидантного …
6-Shogaol inhibits advanced glycation end-products-induced IL-6 and ICAM-1 expression by regulating oxidative responses in human gingival fibroblasts
K Nonaka, M Bando, E Sakamoto, Y Inagaki… - Molecules, 2019 - mdpi.com
Advanced glycation end-products (AGEs) cause diabetes mellitus (DM) complications and
accumulate more highly in periodontal tissues of patients with periodontitis and DM. AGEs …
accumulate more highly in periodontal tissues of patients with periodontitis and DM. AGEs …
Design, synthesis and biological activity of 1, 4-quinone moiety attached to betulin derivatives as potent DT-diaphorase substrate
M Kadela-Tomanek, M Jastrzębska, K Marciniec… - Bioorganic …, 2021 - Elsevier
In this research, betulin derivatives were bonded to the 1, 4-quinone fragment by triazole
linker. Furthermore, the enzymatic assay used has shown that these compounds are a good …
linker. Furthermore, the enzymatic assay used has shown that these compounds are a good …
The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells
In human cancer cells that harbor mutant KRAS and WT p53 (p53), KRAS contributes to the
maintenance of low p53 levels. Moreover, KRAS depletion stabilizes and reactivates p53 …
maintenance of low p53 levels. Moreover, KRAS depletion stabilizes and reactivates p53 …