Preparation, in vitro characterization, and evaluation of polymeric pH-responsive hydrogels for controlled drug release

T Mahmood, RM Sarfraz, A Mahmood… - ACS …, 2024‏ - ACS Publications
The purpose of the current research is to formulate a smart drug delivery system for solubility
enhancement and sustained release of hydrophobic drugs. Drug solubility-related …

Synthesis and characterization of pH responsive alginate based-hydrogels as oral drug delivery carrier

P Ilgin, H Ozay, O Ozay - Journal of Polymer Research, 2020‏ - Springer
As pharmaceutical carrier materials having antibacterial and pH-sensitive properties,
hydrogels have great potential for clinical applications. Alginate based hydrogels were …

[HTML][HTML] A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled …

S Noureen, S Noreen, SA Ghumman… - European Journal of …, 2023‏ - Elsevier
Abstract pH-responsive hydrogels have become effective and attractive materials for the
controlled release of drugs at pre-determined destinations. In the present study, a novel …

[HTML][HTML] Novel Natrosol/Pectin-co-poly (acrylate) based pH-responsive polymeric carrier system for controlled delivery of Tapentadol Hydrochloride

N Zafar, A Mahmood, S Ilyas, H Ijaz, RM Sarfraz… - Saudi Pharmaceutical …, 2023‏ - Elsevier
Abstract Background & Objectives This study aimed to create a controlled delivery system for
Tapentadol Hydrochloride by develo** interpenetrating networks (IPNs) of Natrosol-Pectin …

Design and in vitro evaluation of pH-sensitive crosslinked chitosan-grafted acrylic acid copolymer (CS-co-AA) for targeted drug delivery

H Ijaz, UR Tulain, MU Minhas, A Mahmood… - … Journal of Polymeric …, 2022‏ - Taylor & Francis
In current research study, novel chitosan-based hydrogel was formulated via crosslinking
graft copolymerization of acrylic acid (AA) and chitosan. Potassium persulfate was used as …

Hydrogel-based intelligent delivery system for controlled release of diloxanide furoate

A Mahmood, A Mahmood, RM Sarfraz, H Ijaz, N Zafar… - Polymer Bulletin, 2023‏ - Springer
In current research work, pH responsive pectin-co-poly (MAA) hydrogels containing
diloxanide furoate were developed by graft polymerization of pectin and methacrylic acid, for …

Development of antihyperlipidemic drug loaded β-CD-based microparticulate carrier systems: tuning and optimization

Z Ul Hassan Shah, S Bashir, RM Sarfraz… - Polymer-Plastics …, 2024‏ - Taylor & Francis
Our study focused on develo** and optimizing β-CD-based microparticulate carrier
systems to enhance lovastatin's solubility and systemic availability (LST). Specifically, we …

Facile synthesis of interpenetrating polymeric nexus for controlled drug delivery of 5-fluorouracil (5-FU)

M Malook, A Mahmood, H Ijaz, RM Sarfraz, MR Akram… - Polymer Bulletin, 2024‏ - Springer
The purpose of the current research study was to formulate and evaluate a fenugreek (FG)
and agarose (AG) base hydrogel exploiting pH-responsive attributes and colon targeting of …

Functionalized crosslinked interpenetrating polymeric network for pH responsive colonic drug delivery

F Azam, H Ijaz, J Qureshi - International Journal of Polymeric …, 2021‏ - Taylor & Francis
Current exploration unveils the promising role of arabinoxylan (AX) in targeted delivery of
acid labile active moiety, by using methacrylic acid (MAA) as monomer, N′, N′-methylene …

[HTML][HTML] Cydonia oblonga-Seed-Mucilage-Based pH-Sensitive Graft Copolymer for Controlled Drug Delivery—In Vitro and In Vivo Evaluation

M Sarfraz, UR Tulain, A Erum, NS Malik, A Mahmood… - Pharmaceutics, 2023‏ - mdpi.com
The primary objective of this study was to assess the potential utility of quince seed mucilage
as an excipient within a graft copolymer for the development of an oral-controlled drug …