Elevation of cell-associated HIV-1 transcripts in CSF CD4+ T cells, despite effective antiretroviral therapy, is linked to brain injury

K Suzuki, J Zaunders, TM Gates, A Levert… - Proceedings of the …, 2022 - pnas.org
Antiretroviral therapy (ART) can attain prolonged undetectable HIV-1 in plasma and
cerebrospinal fluid (CSF), but brain injury remains prevalent in people living with HIV-1 …

A systematic review and meta-analysis on the impact of statin treatment in HIV patients on antiretroviral therapy

K Mokgalaboni, WN Phoswa, S Yates… - International Journal of …, 2023 - mdpi.com
The rate of new human immunodeficiency virus (HIV) infections globally is alarming.
Although antiretroviral therapy (ART) improves the quality of life among this group of …

[HTML][HTML] Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are not

HL Aung, KJ Siefried, TM Gates, BJ Brew, L Mao… - …, 2023 - thelancet.com
Background High antiretroviral therapy (ART) coverage and viral suppression among
people with HIV (PWH) in Australia provide a unique context to study individual cognitive …

Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19

WH Khoo, K Jackson, C Phetsouphanh, JJ Zaunders… - Clinical …, 2023 - Elsevier
Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for …

Plasma Human Immunodeficiency Virus 1 RNA and CD4+ T-Cell Counts Are Determinants of Virological Nonsuppression Outcomes With Initial Integrase Inhibitor …

H Álvarez, A Mocroft, L Ryom… - Clinical Infectious …, 2023 - academic.oup.com
Background There are conflicting data regarding baseline determinants of virological
nonsuppression outcomes in persons with human immunodeficiency virus (HIV) starting …

The evolution of assessing central nervous system complications in human immunodeficiency virus: where do we go from here?

RC McIntosh, US Clark, M Cherner… - The Journal of …, 2023 - academic.oup.com
In this fifth decade of the human immunodeficiency virus (HIV) epidemic, central nervous
system (CNS) complications including cognitive impairment and mental health remain a …

Plasma HIV-1 RNA and CD4⁺ T-cell counts are determinants of virological non-suppression outcomes with initial integrase inhibitor-based regimens: A prospective …

H Álvarez, A Mocroft, L Ryom… - Clinical Infectious …, 2023 - discovery.ucl.ac.uk
BACKGROUND: There are conflicting data regarding baseline determinants of virological
non-suppression outcomes in persons with HIV who initiate antiretroviral treatment (ART) …

HIV and Undetectable= Untransmittable (U= U): Decreasing 1 Sexually Transmitted Infection While Addressing Others

LM Bush, C Nguyen, E Maska - Infectious Diseases in Clinical …, 2024 - journals.lww.com
Advances in development of antiretroviral therapy and increased utilization of pre-exposure
prophylaxis agents have effectively decreased the incidence of HIV sexual transmission …

A micro-disc-based multiplex method for monitoring emerging SARS-CoV-2 variants using the molecular diagnostic tool Intelli-OVI

MB Hossain, Y Uchiyama, SA Rajib… - Communications …, 2024 - nature.com
Background Highly transmissible viruses including SARS-CoV-2 frequently accumulate
novel mutations that are detected via high-throughput sequencing. However, there is a need …

Preservation of functionality, immunophenotype, and recovery of HIV RNA from PBMCs cryopreserved for more than 20 years

WB Dyer, K Suzuki, A Levert, M Starr, AR Lloyd… - Frontiers in …, 2024 - frontiersin.org
Background Many research laboratories have long-term repositories of cryopreserved
peripheral blood mononuclear cells (PBMC), which are costly to maintain but are of …