Translational opportunities and challenges of invasive electrodes for neural interfaces

K Shen, O Chen, JL Edmunds, DK Piech… - Nature Biomedical …, 2023 - nature.com
Invasive brain–machine interfaces can restore motor, sensory and cognitive functions.
However, their clinical adoption has been hindered by the surgical risk of implantation and …

Achieving long-term stability of thin-film electrodes for neurostimulation

P Oldroyd, GG Malliaras - Acta Biomaterialia, 2022 - Elsevier
Implantable electrodes that can reliably measure brain activity and deliver an electrical
stimulus to a target tissue are increasingly employed to treat various neurological diseases …

High-density μLED-based optical cochlear implant with improved thermomechanical behavior

E Klein, C Gossler, O Paul, P Ruther - Frontiers in neuroscience, 2018 - frontiersin.org
This study reports the realization of an optical cochlear implant (oCI) with optimized
thermomechanical properties for optogenetic experiments. The oCI probe comprises 144 …

Ultra-capacitive carbon neural probe allows simultaneous long-term electrical stimulations and high-resolution neurotransmitter detection

S Nimbalkar, E Castagnola, A Balasubramani… - Scientific reports, 2018 - nature.com
We present a new class of carbon-based neural probes that consist of homogeneous glassy
carbon (GC) microelectrodes, interconnects and bump pads. These electrodes have purely …

Chronic neural probe for simultaneous recording of single-unit, multi-unit, and local field potential activity from multiple brain sites

F Pothof, L Bonini, M Lanzilotto, A Livi… - Journal of neural …, 2016 - iopscience.iop.org
Objective. Drug resistant focal epilepsy can be treated by resecting the epileptic focus
requiring a precise focus localisation using stereoelectroencephalography (SEEG) probes …

Insulation lifetime improvement of polyimide thin film neural implants

F Ceyssens, R Puers - Journal of neural engineering, 2015 - iopscience.iop.org
Objective. This work deals with studying and improving the insulation lifetime of polyimide-
insulated thin film neural implants, or related polyimide-based medical implants. Approach …

Incorporation of Silicon Carbide and Diamond‐Like Carbon as Adhesion Promoters Improves In Vitro and In Vivo Stability of Thin‐Film Glassy Carbon …

M Vomero, E Castagnola, JS Ordonez… - Advanced …, 2018 - Wiley Online Library
Thin‐film neural devices are an appealing alternative to traditional implants, although their
chronic stability remains matter of investigation. In this study, a chronically stable class of …

Improved polyimide thin-film electrodes for neural implants

JS Ordonez, C Boehler, M Schuettler… - … Conference of the …, 2012 - ieeexplore.ieee.org
Thin-film electrode arrays for neural implants are necessary when large integration densities
of stimulating or recording channels are required. However, delamination of the metallic …

Silicone rubber and thin-film polyimide for hybrid neural interfaces—A MEMS-based adhesion promotion technique

JS Ordonez, C Boehler, M Schuettler… - 2013 6th International …, 2013 - ieeexplore.ieee.org
Strong permanent adhesion between thin-film polyimide (BPDA-PPD) and silicone rubber
(MED-1000) was achieved through deposition of a chemically-transitive intermediate …

Evaluation of adhesion promoters for Parylene C on gold metallization

V Radun, RP Von Metzen, T Stieglitz… - Current Directions in …, 2015 - degruyter.com
Delamination of thin film polymeric coatings from metallization layers is a common cause of
failure in biomedical implants. To address the problem, different adhesion promotion …