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TLR-4: a promising target for chemotherapy-induced peripheral neuropathy
N Babu, A Gadepalli, Akhilesh, D Sharma… - Molecular Biology …, 2024 - Springer
Chemotherapy-induced peripheral neuropathy (CIPN) affects a significant majority of cancer
patients, with up to 80% experiencing this severe and dose-limiting side effect while …
patients, with up to 80% experiencing this severe and dose-limiting side effect while …
Regulatory role of PPAR in colorectal cancer
C Wang, T Lv, B **, Y Li, Z Fan - Cell Death Discovery, 2025 - nature.com
Colorectal cancer (CRC) is one of the most common tumors in the digestive system, and the
majority of patients are found to be in advanced stages, which is a burden to human health …
majority of patients are found to be in advanced stages, which is a burden to human health …
Toxic effect and mRNA mechanism of moon dust simulant induced pulmonary inflammation in rats
J Wang, Y Xue, B Wu, M Lei, H Ma, X He, Q Tan… - Toxicology, 2024 - Elsevier
Moon dust presents a significant hazard to manned moon exploration missions, yet our
understanding of its toxicity remains limited. The objective of this study is to investigate the …
understanding of its toxicity remains limited. The objective of this study is to investigate the …
Decreased Resolvin D1 and Increased Fatty Acid Oxidation Contribute to Severity Score of Krabbe Disease in Twitcher Mice
C Signorini, G Collodel, G Pannuzzo… - JOURNAL OF …, 2024 - usiena-air.unisi.it
Background: Krabbe disease is due to a deficiency of lysosomal enzyme
galactosylceramidase, which leads to destruction of the myelin sheath around nerves in the …
galactosylceramidase, which leads to destruction of the myelin sheath around nerves in the …
A partial agonist of PPARγ prevents paclitaxel‐induced peripheral neuropathy in mice, by inhibiting neuroinflammation
L Benvenutti, FR Wolff, TP Corrêa… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a
common side effect of paclitaxel, affecting 30‐50% of patients. Increased survival and …
common side effect of paclitaxel, affecting 30‐50% of patients. Increased survival and …
Peroxisome proliferator-activated receptor gamma: A promising therapeutic target for the treatment of chronic pain
L Liu, FH Song, SJ Gao, JY Wu, DY Li, LQ Zhang… - Brain Research, 2024 - Elsevier
Chronic pain represents an incapacitating medical condition that profoundly impacts the
patients' quality of life. Managing chronic pain poses a significant challenge for healthcare …
patients' quality of life. Managing chronic pain poses a significant challenge for healthcare …
Suppression of the postprandial hyperglycemia in patients with type 2 diabetes by a raw medicinal herb powder is weakened when consumed in ordinary hard gelatin …
Introduction Contradictory claims about the efficacy of several medicinal plants to promote
glycemic control in patients with type 2 diabetes mellitus (T2DM) have been explained by …
glycemic control in patients with type 2 diabetes mellitus (T2DM) have been explained by …
Characterization of pain-related behaviors and gene expression profiling of peripheral sensory ganglia in a mouse model of acute ankle sprain
Y Pan, Q Hu, Y Yang, H Nie, C Yin, H Wei… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction Lateral ankle sprain (LAS) is a very common type of joint injury. It occurred with
high incidence among general population and especially among individuals participating …
high incidence among general population and especially among individuals participating …
Animal models of neuropathic pain
AM Casaril, CM Gaffney… - Neuropathic …, 2024 - mdanderson.elsevierpure.com
Animal models continue to be crucial to develo** our understanding of the molecular,
cellular, and neurophysiological mechanisms that lead to neuropathic pain. The …
cellular, and neurophysiological mechanisms that lead to neuropathic pain. The …