The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many
fundamental processes, including embryonic development and tissue homeostasis …

Recent studies have shown that T cells are not just the latecomers in inflammation but might
also play a key role in the early phase of this response. In this context, a number of T cell …

Abstract β-catenin is a central molecule in the Wnt pathway. Expression of a stable form of β-
catenin on CD4+ CD25+ regulatory T (Treg) cells resulted in a marked enhancement of …

Current cancer therapies target the bulk of the tumour, while a population of highly resistant
tumour cells may be able to repopulate the tumour and metastasize to new sites. Cancer …

The production of mature functional T cells in the thymus requires signals from the thymic
epithelium. Here, we review recent experiments showing that one way in which the …

Abstract Purpose: Basal cell carcinomas (BCCs) are tumors ignored by immune
surveillance. Activated Hedgehog (Hh) signaling within primary cilia is a key driver in the …

Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast,
pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …

Breast cancer ranks as one of the most common malignancies among women, with its
prognosis and therapeutic efficacy heavily influenced by factors associated with the tumor …