Cardiac excitation–contraction coupling occurs primarily at the sites of transverse (T)-
tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the …

The transverse tubules (t-tubules) are invaginations of the cell membrane rich in several ion
channels and other proteins devoted to the critical task of excitation–contraction coupling in …

The Deepwater Horizon oil spill disaster in 2010 led to the discharge of 4.9 million barrels of
oil into the Gulf of Mexico. This occurred during the peak spawning time for the severely …

Heart muscle is characterized by a regular array of proteins and structures that form a
repeating functional unit identified as the sarcomere. This regular structure enables tight …

T-tubular invaginations of the sarcolemma of ventricular cardiomyocytes contain junctional
structures functionally coupling L-type calcium channels to the sarcoplasmic reticulum …

The mutational origin and subsequent evolution of de novo genes, which are hypothesized
to be genes of recent origin that are not obviously related to ancestral coding sequence, are …

Rationale: Transverse tubules (t-tubules) regulate cardiac excitation–contraction coupling
and exhibit interchamber and interspecies differences in expression. In cardiac disease, t …

Hypertrophic cardiomyopathy (HCM) is the most common mendelian heart disease, with a
prevalence of 1/500. HCM is a primary cause of sudden death, due to an heightened risk of …

The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic
reticulum (SR) transmembrane protein that plays a central role in excitation–contraction …

Narrow, tubular, inward projections of the sarcolemma ('T-tubules') are an established
feature of adult mammalian ventricular myocytes that enables them to generate the whole …