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Asymmetric one-pot synthesis of 1, 3-oxazolidines and 1, 3-oxazinanes via hemiaminal intermediates
A highly efficient method for the enantioselective one-pot synthesis of 1, 3-oxazolidines and
1, 3-oxazinanes has been reported. The reaction proceeds via the formation of hemiaminal …
1, 3-oxazinanes has been reported. The reaction proceeds via the formation of hemiaminal …
New Zealand glowworm (Arachnocampa luminosa) bioluminescence is produced by a firefly-like luciferase but an entirely new luciferin
Abstract The New Zealand glowworm, Arachnocampa luminosa, is well-known for displays
of blue-green bioluminescence, but details of its bioluminescent chemistry have been …
of blue-green bioluminescence, but details of its bioluminescent chemistry have been …
Ralph F. Hirschmann award address 2009: Merger of organic chemistry with peptide diversity
A huge unleashed potential lies hidden in the large and diverse pool of encoded and
particularly nonencoded chiral α‐, β‐, and γ‐amino acids available today. Although these …
particularly nonencoded chiral α‐, β‐, and γ‐amino acids available today. Although these …
Efficient Solid‐Phase Synthesis of Peptide‐Based Phosphine Ligands: Towards Combinatorial Libraries of Selective Transition Metal Catalysts
A new methodology for the solid‐phase synthesis of peptide‐based phosphine ligands has
been developed. Solid supported peptide scaffolds possessing either primary or secondary …
been developed. Solid supported peptide scaffolds possessing either primary or secondary …
Solid‐Phase Synthesis of Tetrahydro‐β‐carbolines and Tetrahydroisoquinolines by Stereoselective Intramolecular N‐Carbamyliminium Pictet–Spengler Reactions
A solid‐phase method for the synthesis of tri‐, tetra‐, and pentacyclic compounds containing
tetrahydro‐β‐carboline, tetrahydroisoquinoline or analogous scaffolds is presented. The …
tetrahydro‐β‐carboline, tetrahydroisoquinoline or analogous scaffolds is presented. The …
Facile synthesis of SAM–peptide conjugates through alkyl linkers targeting protein N-terminal methyltransferase 1
We report the first chemical synthesis of SAM–peptide conjugates through alkyl linkers to
prepare bisubstrate analogs for protein methyltransferases. We demonstrate its application …
prepare bisubstrate analogs for protein methyltransferases. We demonstrate its application …
Solid-phase synthesis of a peptide-based P, S-ligand system designed for generation of combinatorial catalyst libraries
An efficient methodology for the solid-phase synthesis of diverse combinatorial peptide-
based P, S-ligand libraries based on a modular approach was developed. Chiral thioethers …
based P, S-ligand libraries based on a modular approach was developed. Chiral thioethers …
Versatile Synthesis of Free and N‐Benzyloxycarbonyl‐Protected 2,2‐Disubstituted Taurines
B Wang, W Zhang, L Zhang, DM Du, G Liu, J Xu - 2008 - Wiley Online Library
An effective and versatile method was developed to synthesize N‐benzyloxycarbonyl‐
protected and free 2, 2‐disubstituted taurines. Several novel 2, 2‐disubstituted taurines …
protected and free 2, 2‐disubstituted taurines. Several novel 2, 2‐disubstituted taurines …
Diversity‐Oriented Syntheses by Combining CuAAC and Stereoselective INCIC Reactions with Peptides
Cascade reactions proceeding through peptide‐derived N‐carbamoyl iminium ions are
reported. Two new reactions of N‐carbamoyl iminium ions are described, including a …
reported. Two new reactions of N‐carbamoyl iminium ions are described, including a …
Efficient 'one-pot'methodology for the synthesis of novel tetrahydro-β-carboline, tetrahydroisoquinoline and tetrahydrothienopyridine derivatives
A Ionescu, D Cornut, S Soriano, C Guissart… - Tetrahedron …, 2013 - Elsevier
A simple and efficient 'one-pot'methodology was developed to generate a new series of
tetrahydro-β-carboline (THBC), tetrahydroisoquinoline (THIQ) and tetrahydrothienopyridine …
tetrahydro-β-carboline (THBC), tetrahydroisoquinoline (THIQ) and tetrahydrothienopyridine …