Outer membrane protein biogenesis in Gram-negative bacteria
SE Rollauer, MA Sooreshjani… - … Transactions of the …, 2015 - royalsocietypublishing.org
Gram-negative bacteria contain a double membrane which serves for both protection and for
providing nutrients for viability. The outermost of these membranes is called the outer …
providing nutrients for viability. The outermost of these membranes is called the outer …
Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria
β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …
The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase
Antibiotics that target Gram-negative bacteria in new ways are needed to resolve the
antimicrobial resistance crisis,–. Gram-negative bacteria are protected by an additional outer …
antimicrobial resistance crisis,–. Gram-negative bacteria are protected by an additional outer …
The β-barrel assembly machinery in motion
In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins (OMPs) is
mediated by the β-barrel assembly machinery (BAM) complex. During the past decade …
mediated by the β-barrel assembly machinery (BAM) complex. During the past decade …
Cryo-EM structures reveal multiple stages of bacterial outer membrane protein folding
Transmembrane β barrel proteins are folded into the outer membrane (OM) of Gram-
negative bacteria by the β barrel assembly machinery (BAM) via a poorly understood …
negative bacteria by the β barrel assembly machinery (BAM) via a poorly understood …
[HTML][HTML] Type V secretion: from biogenesis to biotechnology
The two membranes of Gram-negative bacteria contain protein machines that have a
general function in their assembly. To interact with the extra-cellular milieu, Gram-negatives …
general function in their assembly. To interact with the extra-cellular milieu, Gram-negatives …
Yersinia adhesin A (YadA)–beauty & beast
M Mühlenkamp, P Oberhettinger, JC Leo… - International Journal of …, 2015 - Elsevier
The trimeric autotransporter adhesin Yersinia adhesin A is the prototype of the type Vc
secretion systems. It is expressed by enteropathogenic Yersinia enterocolitica and Yersinia …
secretion systems. It is expressed by enteropathogenic Yersinia enterocolitica and Yersinia …
Bacterial outer membrane proteins are targeted to the bam complex by two parallel mechanisms
Membrane proteins that are integrated into the outer membrane of Gram-negative bacteria
typically contain a unique “β barrel” structure that serves as a membrane spanning segment …
typically contain a unique “β barrel” structure that serves as a membrane spanning segment …
[HTML][HTML] The big BAM theory: An open and closed case?
R Wu, R Stephenson, A Gichaba, N Noinaj - Biochimica et Biophysica Acta …, 2020 - Elsevier
The β-barrel assembly machinery (BAM) is responsible for the biogenesis of outer
membrane proteins (OMPs) into the outer membranes of Gram-negative bacteria. These …
membrane proteins (OMPs) into the outer membranes of Gram-negative bacteria. These …
[HTML][HTML] Transmembrane β-barrels: Evolution, folding and energetics
The biogenesis of transmembrane β-barrels (outer membrane proteins, or OMPs) is an
elaborate multistep orchestration of the nascent polypeptide with translocases, barrel …
elaborate multistep orchestration of the nascent polypeptide with translocases, barrel …