Nucleic acid sensing is a central process in the immune system, with far-reaching roles in
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …

Diffuse midline glioma (DMG) is a heterogeneous group of aggressive pediatric brain tumors
with a fatal prognosis. The biological hallmark in the major part of the cases is H3K27 …

Curaxin CBL0137 was designed to regulate p53 and nuclear factor-κB simultaneously and
exhibits antitumor activity by inhibiting tumor cell proliferation and inducing apoptosis in …

Transcription elongation requires elaborate coordination between the transcriptional
machinery and chromatin regulatory factors to successfully produce RNA while preserving …

Epigenetic genome regulation during malignant cell transformation is characterized by the
aberrant methylation and acetylation of histones. Vorinostat (SAHA) is an epigenetic …

Conclusions: Our findings illustrate the cellular architecture and developmental trajectories
of HB via integrative bulk and single‐cell transcriptome analyses, thus establishing a …

Even with a rare occurrence of only 1.35% of cancer cases in the United States of America,
brain tumors are considered as one of the most lethal malignancies. The most aggressive …

DNA double‐strand breaks (DSBs) yield highly determines radiotherapy efficacy. However,
improving the inherent radiosensitivity of tumor DNA to promote radiation‐induced DSBs …

Abstract H3 K27M-mutant diffuse glioma is a recently identified brain tumor associated with
poor prognosis. As of 2016, it is classified by the World Health Organization as a distinct …

Background Diffuse pleural mesothelioma (DPM) is an aggressive therapy-resistant cancer
with unique molecular features. Numerous agents have been tested, but clinically effective …