Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
Calcineurin is important for fungal virulence and a potential antifungal target, but
compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report …
compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report …
An Efficient synthesis of Weinreb amides and ketones via palladium nanoparticles on ZIF-8 catalysed carbonylative coupling
Heterogeneously catalysed carbonylative coupling reactions such as aminocarbonylation
and Suzuki-carbonylation are reported using Pd nanoparticles supported on ZIF-8 for …
and Suzuki-carbonylation are reported using Pd nanoparticles supported on ZIF-8 for …
Antiviral indoleoxoacetyl piperazine derivatives
WS Blair, M Deshpande, H Fang, PF Lin… - US Patent …, 2002 - Google Patents
This invention provides compounds having drug and bio affecting properties, their
pharmaceutical compositions and method of use. In particular, the invention is concerned …
pharmaceutical compositions and method of use. In particular, the invention is concerned …
Pipecolic acid derivatives for vision and memory disorders
DT Ross, H Sauer, GS Hamilton, JP Steiner - US Patent 6,376,517, 2002 - Google Patents
EP 405994 1/1991 EP 419049 3/1991 EP 468339 1/1992 EP 572365 12/1993 EP 652229
5/1995 GB 2247456 3/1992 JP 05178824 7/1993 WO WO9313066 7/1983 WO WO8809789 …
5/1995 GB 2247456 3/1992 JP 05178824 7/1993 WO WO9313066 7/1983 WO WO8809789 …
Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
GS Hamilton, MH Norman, YQ Wu - US Patent 6,331,537, 2001 - Google Patents
This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid
isosteres, their preparation and use for treating neurological disorders including physically …
isosteres, their preparation and use for treating neurological disorders including physically …
Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
OB Wallace, T Wang, KS Yeung, BC Pearce… - US Patent …, 2003 - Google Patents
2002-02-12 Assigned to BRISTOL-MYERS SQUIBB COMPANY reassignment BRISTOL-
MYERS SQUIBB COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
MYERS SQUIBB COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Indole, azaindole and related heterocyclic amidopiperazine derivatives
T Wang, OB Wallace, NA Meanwell, Z Zhang… - US Patent …, 2004 - Google Patents
US6825201B2 - Indole, azaindole and related heterocyclic amidopiperazine derivatives -
Google Patents US6825201B2 - Indole, azaindole and related heterocyclic …
Google Patents US6825201B2 - Indole, azaindole and related heterocyclic …
An expedient conversion of α-amino acids into Weinreb amides using COMU® as a coupling agent
E Tyrrell, P Brawn, M Carew, I Greenwood - Tetrahedron Letters, 2011 - Elsevier
The use of COMU®, as a non-hazardous partner, in the coupling of N-protected α-amino
acids to N-methoxy-N-methylamine to afford the corresponding Weinreb amides is …
acids to N-methoxy-N-methylamine to afford the corresponding Weinreb amides is …
Design, synthesis and evaluation of dual domain FKBP ligands
DS Yamashita, HJ Oh, HK Yen, MJ Bossard… - Bioorganic & Medicinal …, 1994 - Elsevier
A number of dual domain acyclic and macrocyclic pipecolyl α-ketoamide derivatives were
prepared which possess the elements of previously described high-affinity FKBP binding …
prepared which possess the elements of previously described high-affinity FKBP binding …
Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
GS Hamilton, MH Norman, YQ Wu - US Patent 7,153,883, 2006 - Google Patents
This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres,
their preparation and use for treating neurological disorders including physically damaged …
their preparation and use for treating neurological disorders including physically damaged …