RSK inhibitors as potential anticancer agents: discovery, optimization, and challenges

Y Sun, L Tang, C Wu, J Wang, C Wang - European Journal of Medicinal …, 2023 - Elsevier
Ribosomal S6 kinase (RSK) family is a group of serine/threonine kinases, including four
isoforms (RSK1/2/3/4). As a downstream effector of the Ras-mitogen-activated protein …

ZAP-70 augments tonic B-cell receptor and CCR7 signaling in IGHV–unmutated chronic lymphocytic leukemia

J Chen, V Sathiaseelan… - Blood …, 2024 - ashpublications.org
Expression of ZAP-70 in a subset of patients with chronic lymphocytic leukemia (CLL)
positively correlates with the absence of immunoglobulin heavy-chain gene (IGHV) …

TEM1 up-regulates MMP-2 and promotes ECM remodeling for facilitating invasion and migration of uterine sarcoma

C Wu, W Sun, D Shen, H Li, X Tong, Y Guo - Discover Oncology, 2023 - Springer
Objectives To explore the correlation between tumor endothelial marker 1 (TEM1) and
matrix metalloproteinase 2 (MMP-2) in uterine sarcoma and their roles in the progression of …

T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway

SY Park, H Choi, SM Choi, S Wang, S Shim… - BMB …, 2024 - pmc.ncbi.nlm.nih.gov
T-plastin (PLST), a member of the actin-bundling protein family, plays crucial roles in
cytoskeletal structure, regulation, and motility. Studies have shown that the plastin family is …

ROK and RSK2-kinase pathways differ between senescent human renal and mesenteric arteries

LT Lubomirov, R Mantke, T Enzmann… - Journal of …, 2023 - journals.lww.com
Objective: Small arteries from different organs vary with regard to the mechanisms that
regulate vasoconstriction. This study investigated the impact of advanced age on the …

Expression of non-phosphorylatable S5A-L-plastin exerts phenotypes distinct from L-plastin deficiency during podosome formation and phagocytosis

X Lin, P Krishnamoorthy, EC Walker, H Joshi… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: The actin cytoskeleton remodels to enable diverse processes essential to
immunity, such as cell adhesion, migration and phagocytosis. A panoply of actin-binding …

Phospho-proteomics reveals that RSK signaling is required for proliferation of natural killer cells stimulated with IL-2 or IL-15

MA MacMullan, P Wang, NA Graham - Cytokine, 2022 - Elsevier
Natural killer (NK) cells are cytotoxic lymphocytes that play a critical role in the innate
immune system. Although cytokine signaling is crucial for the development, expansion, and …

LCP1 Regulates Cell Motility in Chondrosarcoma and Correlates with Metastatic Potential and Poor Patient Outcomes

C Watson, JT Martin, M Nakagawa, N Guardino, T Zou… - bioRxiv, 2023 - biorxiv.org
Chondrosarcoma (CSA) is the second most common primary malignancy of bone, whose
aggressive potential and chemo-resistant nature result in extremely poor outcomes in …

Neutrophil biomechanical properties and immune function in health and inflammatory disease

K Bashant - 2021 - repository.cam.ac.uk
Low density granulocytes (LDGs) are a poorly understood class of immune cells found in
patients with chronic inflammatory diseases including psoriasis and systemic lupus …

[PDF][PDF] Discover Oncology

C Zhou, YQ Huang, MX Da, WL **, FH Zhou - Discover, 2023 - researchgate.net
By the year 2035 more than 4 billion people might be affected by obesity and being
overweight. Adipocyte-derived Extracellular Vesicles (ADEVs/ADEV-singular) are essential …