RSK inhibitors as potential anticancer agents: discovery, optimization, and challenges
Ribosomal S6 kinase (RSK) family is a group of serine/threonine kinases, including four
isoforms (RSK1/2/3/4). As a downstream effector of the Ras-mitogen-activated protein …
isoforms (RSK1/2/3/4). As a downstream effector of the Ras-mitogen-activated protein …
ZAP-70 augments tonic B-cell receptor and CCR7 signaling in IGHV–unmutated chronic lymphocytic leukemia
J Chen, V Sathiaseelan… - Blood …, 2024 - ashpublications.org
Expression of ZAP-70 in a subset of patients with chronic lymphocytic leukemia (CLL)
positively correlates with the absence of immunoglobulin heavy-chain gene (IGHV) …
positively correlates with the absence of immunoglobulin heavy-chain gene (IGHV) …
TEM1 up-regulates MMP-2 and promotes ECM remodeling for facilitating invasion and migration of uterine sarcoma
C Wu, W Sun, D Shen, H Li, X Tong, Y Guo - Discover Oncology, 2023 - Springer
Objectives To explore the correlation between tumor endothelial marker 1 (TEM1) and
matrix metalloproteinase 2 (MMP-2) in uterine sarcoma and their roles in the progression of …
matrix metalloproteinase 2 (MMP-2) in uterine sarcoma and their roles in the progression of …
T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway
SY Park, H Choi, SM Choi, S Wang, S Shim… - BMB …, 2024 - pmc.ncbi.nlm.nih.gov
T-plastin (PLST), a member of the actin-bundling protein family, plays crucial roles in
cytoskeletal structure, regulation, and motility. Studies have shown that the plastin family is …
cytoskeletal structure, regulation, and motility. Studies have shown that the plastin family is …
ROK and RSK2-kinase pathways differ between senescent human renal and mesenteric arteries
LT Lubomirov, R Mantke, T Enzmann… - Journal of …, 2023 - journals.lww.com
Objective: Small arteries from different organs vary with regard to the mechanisms that
regulate vasoconstriction. This study investigated the impact of advanced age on the …
regulate vasoconstriction. This study investigated the impact of advanced age on the …
Expression of non-phosphorylatable S5A-L-plastin exerts phenotypes distinct from L-plastin deficiency during podosome formation and phagocytosis
Introduction: The actin cytoskeleton remodels to enable diverse processes essential to
immunity, such as cell adhesion, migration and phagocytosis. A panoply of actin-binding …
immunity, such as cell adhesion, migration and phagocytosis. A panoply of actin-binding …
Phospho-proteomics reveals that RSK signaling is required for proliferation of natural killer cells stimulated with IL-2 or IL-15
Natural killer (NK) cells are cytotoxic lymphocytes that play a critical role in the innate
immune system. Although cytokine signaling is crucial for the development, expansion, and …
immune system. Although cytokine signaling is crucial for the development, expansion, and …
LCP1 Regulates Cell Motility in Chondrosarcoma and Correlates with Metastatic Potential and Poor Patient Outcomes
Chondrosarcoma (CSA) is the second most common primary malignancy of bone, whose
aggressive potential and chemo-resistant nature result in extremely poor outcomes in …
aggressive potential and chemo-resistant nature result in extremely poor outcomes in …
Neutrophil biomechanical properties and immune function in health and inflammatory disease
K Bashant - 2021 - repository.cam.ac.uk
Low density granulocytes (LDGs) are a poorly understood class of immune cells found in
patients with chronic inflammatory diseases including psoriasis and systemic lupus …
patients with chronic inflammatory diseases including psoriasis and systemic lupus …
[PDF][PDF] Discover Oncology
C Zhou, YQ Huang, MX Da, WL **, FH Zhou - Discover, 2023 - researchgate.net
By the year 2035 more than 4 billion people might be affected by obesity and being
overweight. Adipocyte-derived Extracellular Vesicles (ADEVs/ADEV-singular) are essential …
overweight. Adipocyte-derived Extracellular Vesicles (ADEVs/ADEV-singular) are essential …