Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …

Glutamate-mediated excitotoxicity, neuroinflammation, and oxidative stress are common
underlying events in neurodegeneration. This pathogenic “triad” characterizes the …

Understanding seizure formation and spread remains a critical goal of epilepsy research.
We used fast in vivo two-photon calcium imaging in male mouse neocortex to reconstruct …

Single-unit recordings performed in temporal lobe epilepsy patients and in models of
temporal lobe seizures have shown that interneurons are active at focal seizure onset. We …

Interictal epileptiform discharges (IEDs) are a widely used biomarker in patients with
epilepsy but lack specificity. It has been proposed that there are truly epileptogenic and less …

Epilepsy is the most common neurological disorder, affecting nearly 50 million people
worldwide. The condition can be manifested either due to genetic predisposition or acquired …

Epilepsy is based on abnormal neuronal activities that have historically been suggested to
arise from an excess of excitation and a defect of inhibition, or in other words from an …

Due to its complex and multifaceted nature, develo** effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

With their 'all-or-none'action potential responses, single neurons (or units) are accepted as
the basic computational unit of the brain. There is extensive animal literature to support the …