Further developments and applications of oxazoline-containing ligands in asymmetric catalysis

R Connon, B Roche, BV Rokade, PJ Guiry - Chemical Reviews, 2021 - ACS Publications
The chiral oxazoline motif is present in many ligands that have been extensively applied in a
series of important metal-catalyzed enantioselective reactions. This Review aims to provide …

Development of and recent advances in asymmetric A3 coupling

BV Rokade, J Barker, PJ Guiry - Chemical Society Reviews, 2019 - pubs.rsc.org
Asymmetric A3 coupling has emerged as an important class of reactions to synthesise chiral
propargylamines. In this tutorial review, an up to date progress of this reaction, with …

Atomically precise ultrasmall copper cluster for room-temperature highly regioselective dehydrogenative coupling

T Jia, YX Li, XH Ma, MM Zhang, XY Dong, J Ai… - Nature …, 2023 - nature.com
Three-component dehydrogenative coupling reactions represent important and practical
methodologies for forging new C–N bonds and C–C bonds. Achieving highly all-in-one …

Visible‐light‐induced palladium‐catalyzed generation of aryl radicals from aryl triflates

M Ratushnyy, N Kvasovs, S Sarkar… - Angewandte Chemie …, 2020 - Wiley Online Library
A mild visible‐light‐induced Pd‐catalyzed intramolecular C− H arylation of amides is
reported. The method operates by cleavage of a C (sp2)− O bond, leading to hybrid aryl Pd …

A3 Coupling Reaction in the Synthesis of Heterocyclic Compounds

Y Volkova, S Baranin, I Zavarzin - Advanced Synthesis & …, 2021 - Wiley Online Library
In recent years, the transition‐metal catalyzed three‐component coupling of an aldehyde, an
alkyne and an amine, commonly called A3 coupling has become a powerful tool in organic …

Catalytic Asymmetric Reactions with N,O-Aminals

YY Huang, C Cai, X Yang, ZC Lv, U Schneider - ACS Catalysis, 2016 - ACS Publications
N, O-aminals, molecules bearing a geminally N, O-substituted (stereogenic) carbon center,
have been recently recognized as an important class of building blocks in organic synthesis …

Highly enantioselective synthesis of propargyl amides through Rh-catalyzed asymmetric hydroalkynylation of enamides: scope, mechanism, and origin of selectivity

XY Bai, WW Zhang, Q Li, BJ Li - Journal of the American Chemical …, 2018 - ACS Publications
Chiral propargyl amides are particularly useful structural units in organic synthesis. The
enantioselective synthesis of propargyl amide is highly desirable. Conventional approach …

Metal-Catalysed A3 Coupling Methodologies: Classification and Visualisation

J Farhi, IN Lykakis, GE Kostakis - Catalysts, 2022 - mdpi.com
The multicomponent reaction of aldehydes, amines, and alkynes, known as A3 coupling,
yields propargylamines, a valuable organic scaffold, and has received significant interest …

Isoindolinone Synthesis via One‐Pot Type Transition Metal Catalyzed C− C Bond Forming Reactions

R Savela, C Méndez‐Gálvez - Chemistry–A European Journal, 2021 - Wiley Online Library
Isoindolinone structure is an important privileged scaffold found in a large variety of naturally
occurring as well as synthetic, biologically and pharmaceutically active compounds. Owing …

Electrochemically enabled intramolecular and intermolecular annulations of alkynes

K Sun, J Lei, Y Liu, B Liu, N Chen - Advanced Synthesis & …, 2020 - Wiley Online Library
Electrosynthesis is recognized as one of the most powerful and sustainable methods in
organic chemistry. Recently, electrochemically enabled annulations of carbon‐carbon triple …