Over the last two decades, calcium silicate-based materials have grown in popularity. As
root canal sealers, these formulations have been extensively investigated and compared …

Bioceramics have been used for the replacement and repair of damaged hard tissues for
about 50 years, in which the mechanical properties and biocompatibility of the materials are …

Bioactive ions released from bioceramics play important roles in bone regeneration;
however, it is unclear how each ionic composition in complex bioceramics exerts its specific …

Regeneration of large-size bone defects represents a significant challenge clinically, which
requires the use of scaffolds with multifunction, such as anti-bacterial activity, and stimulation …

The periosteum plays an important role in the regeneration of critical-size bone defects, with
functions of recruiting multiple cells, accelerating vascular network reconstruction, and …

Silicate bioceramics, as a new family of biomaterials, have received significant attention in
their application to hard tissue regeneration. Some silicate bioceramics have shown …

Immune reactions are a key factor in determining the destiny of bone substitute materials
after implantation. Macrophages, the most vital factor in the immune response affecting …

Although much research has gone into the design of nanomaterials, inflammatory response
still impedes the capacity of nanomaterial-induced tissue regeneration. In-situ incorporation …

Severe injuries and diseases of bone tissue caused by congenital disorder, extrinsic trauma,
infection, and osteosarcoma resection face significant challenges for complete recovery. The …

The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …