Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient. When these recommendations are implemented patient …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient, which when implemented may improve patient outcomes …

Background: Red blood cell (RBC) transfusions are common in intensive care unit, trauma,
and surgical patients. However, the hematocrit that should be maintained in any particular …

Objective: To develop a clinical practice guideline for red blood cell transfusion in adult
trauma and critical care. Design: Meetings, teleconferences and electronic-based …

Massive transfusion (MT) is a lifesaving treatment of hemorrhagic shock, but can be
associated with significant complications. The lethal triad of acidosis, hypothermia, and …

Background We have previously shown that blood transfusion in the first 24 hours is an
independent predictor of mortality, intensive care unit (ICU) admission, and increased ICU …

Red cell (RBC) transfusions are a potentially life‐saving therapy employed during the care
of many critically ill patients to replace losses in hemoglobin to maintain oxygen delivery to …