Cardiac fibrosis

NG Frangogiannis - Cardiovascular research, 2021 - academic.oup.com
Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Cellular and molecular pathobiology of heart failure with preserved ejection fraction

S Mishra, DA Kass - Nature Reviews Cardiology, 2021 - nature.com
Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Biomarkers for the diagnosis and management of heart failure

V Castiglione, A Aimo, G Vergaro, L Saccaro… - Heart failure …, 2022 - Springer
Heart failure (HF) is a significant cause of morbidity and mortality worldwide. Circulating
biomarkers reflecting pathophysiological pathways involved in HF development and …

Inflammatory cytokines and chemokines as therapeutic targets in heart failure

A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …

Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies

SJ Pocock, CA Ariti, JJV McMurray… - European heart …, 2013 - academic.oup.com
Aims Using a large international database from multiple cohort studies, the aim is to create a
generalizable easily used risk score for mortality in patients with heart failure (HF). Methods …

Heart failure with preserved ejection fraction

CE Hamo, C DeJong, N Hartshorne-Evans… - Nature reviews Disease …, 2024 - nature.com
Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart
failure cases and has a prevalence that is expected to rise with the growing ageing …

Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models

C Withaar, CSP Lam, GG Schiattarella… - European heart …, 2021 - academic.oup.com
Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …

Metabolomic machine learning predictor for diagnosis and prognosis of gastric cancer

Y Chen, B Wang, Y Zhao, X Shao, M Wang… - Nature …, 2024 - nature.com
Gastric cancer (GC) represents a significant burden of cancer-related mortality worldwide,
underscoring an urgent need for the development of early detection strategies and precise …

Phenomap** in heart failure with preserved ejection fraction: insights, limitations, and future directions

AE Peters, J Tromp, SJ Shah, CSP Lam… - Cardiovascular …, 2022 - academic.oup.com
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous entity with
complex pathophysiology and manifestations. Phenomap** is the process of applying …

Chronic low‐grade inflammation in heart failure with preserved ejection fraction

T Mesquita, YN Lin, A Ibrahim - Aging Cell, 2021 - Wiley Online Library
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form
of HF with a dramatic increase in risk with age. Low‐grade inflammation, as occurs with …