Breathing movements in mammals are driven by rhythmic neural activity generated within
spatially and functionally organized brainstem neural circuits comprising the respiratory …

Breathing is an essential behavior that presents a unique opportunity to understand how the
nervous system functions normally, how it balances inherent robustness with a highly …

Communication between neurons rests on their capacity to change their firing pattern to
encode different messages. For several vital functions, such as respiration and mastication …

The analgesic utility of opioid-based drugs is limited by the life-threatening risk of respiratory
depression. Opioid-induced respiratory depression (OIRD), mediated by the μ-opioid …

We assessed the mechanism of mammalian breathing rhythmogenesis in the preBötzinger
complex (preBötC) in vitro, where experimental tests remain inconsistent with hypotheses of …

Flufenamic acid has been known since the 1960s to have anti-inflammatory properties
attributable to the reduction of prostaglandin synthesis. Thirty years later, flufenamic acid …

The basic pattern of rhythmic jaw movements produced during mastication is generated by a
neuronal network located in the brainstem and referred to as the masticatory central pattern …

Breathing's remarkable ability to adapt to changes in metabolic, environmental, and
behavioral demands stems from a complex integration of its rhythm-generating network …

In 1996, we published a review article (Marder E, Calabrese RL. Physiol Rev 76: 687–717,
1996) describing the state of knowledge about the structure and function of the central …

We comparatively analyzed cellular and circuit properties of identified rhythmic excitatory
and inhibitory interneurons within respiratory microcircuits of the neonatal rodent pre …