Gastroenteropancreatic neuroendocrine tumors

J Strosberg - The American Cancer Society's Oncology in …, 2018 - Wiley Online Library
Neuroendocrine tumors (NETs) are heterogeneous neoplasms that vary considerably based
on primary site, differentiation, and grade. A minority of NETs are characterized by the ability …

[HTML][HTML] Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells

U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

[HTML][HTML] A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization …

G Rindi, DS Klimstra, B Abedi-Ardekani, SL Asa… - Modern Pathology, 2018 - Elsevier
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …

Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled …

JC Yao, N Fazio, S Singh, R Buzzoni, C Carnaghi… - The Lancet, 2016 - thelancet.com
Background Effective systemic therapies for patients with advanced, progressive
neuroendocrine tumours of the lung or gastrointestinal tract are scarce. We aimed to assess …

Whole-genome landscape of pancreatic neuroendocrine tumours

A Scarpa, DK Chang, K Nones, V Corbo, AM Patch… - Nature, 2017 - nature.com
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …

Drugging the undruggable RAS: Mission possible?

AD Cox, SW Fesik, AC Kimmelman, J Luo… - Nature reviews Drug …, 2014 - nature.com
Despite more than three decades of intensive effort, no effective pharmacological inhibitors
of the RAS oncoproteins have reached the clinic, prompting the widely held perception that …

Oncotator: cancer variant annotation tool

AH Ramos, L Lichtenstein, M Gupta… - Human …, 2015 - Wiley Online Library
Oncotator is a tool for annotating genomic point mutations and short nucleotide
insertions/deletions (indels) with variant‐and gene‐centric information relevant to cancer …

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

J van Riet, HJG van de Werken, E Cuppen… - Nature …, 2021 - nature.com
Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 …

WM Hackeng, LAA Brosens, JY Kim, R O'Sullivan… - Gut, 2022 - gut.bmj.com
Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …

Genetics and epigenetics of gastroenteropancreatic neuroendocrine neoplasms

A Mafficini, A Scarpa - Endocrine reviews, 2019 - academic.oup.com
Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …