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Gastroenteropancreatic neuroendocrine tumors
J Strosberg - The American Cancer Society's Oncology in …, 2018 - Wiley Online Library
Neuroendocrine tumors (NETs) are heterogeneous neoplasms that vary considerably based
on primary site, differentiation, and grade. A minority of NETs are characterized by the ability …
on primary site, differentiation, and grade. A minority of NETs are characterized by the ability …
[HTML][HTML] Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
[HTML][HTML] A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization …
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …
currently causes considerable confusion. A uniform classification framework for NENs at any …
Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled …
JC Yao, N Fazio, S Singh, R Buzzoni, C Carnaghi… - The Lancet, 2016 - thelancet.com
Background Effective systemic therapies for patients with advanced, progressive
neuroendocrine tumours of the lung or gastrointestinal tract are scarce. We aimed to assess …
neuroendocrine tumours of the lung or gastrointestinal tract are scarce. We aimed to assess …
Whole-genome landscape of pancreatic neuroendocrine tumours
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …
more sensitive detection methods, and this increase is creating challenges for clinical …
Drugging the undruggable RAS: Mission possible?
AD Cox, SW Fesik, AC Kimmelman, J Luo… - Nature reviews Drug …, 2014 - nature.com
Despite more than three decades of intensive effort, no effective pharmacological inhibitors
of the RAS oncoproteins have reached the clinic, prompting the widely held perception that …
of the RAS oncoproteins have reached the clinic, prompting the widely held perception that …
Oncotator: cancer variant annotation tool
AH Ramos, L Lichtenstein, M Gupta… - Human …, 2015 - Wiley Online Library
Oncotator is a tool for annotating genomic point mutations and short nucleotide
insertions/deletions (indels) with variant‐and gene‐centric information relevant to cancer …
insertions/deletions (indels) with variant‐and gene‐centric information relevant to cancer …
The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets
Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) form clinically and
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …
genetically heterogeneous malignancies, characterized by distinct prognoses based upon …
Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 …
Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …
and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked …
Genetics and epigenetics of gastroenteropancreatic neuroendocrine neoplasms
A Mafficini, A Scarpa - Endocrine reviews, 2019 - academic.oup.com
Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …