Targeting fibrosis: mechanisms and clinical trials

M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H **ao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

[HTML][HTML] Antidiabetic agents as a novel treatment for Alzheimer's and Parkinson's disease

J Nowell, E Blunt, D Gupta, P Edison - Ageing research reviews, 2023 - Elsevier
Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

Glucagon-like peptide-1: a focus on neurodegenerative diseases

M Grieco, A Giorgi, MC Gentile, M d'Erme… - Frontiers in …, 2019 - frontiersin.org
Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis
of brain impairment caused by chronic hyperglycemia is complex and includes …

[HTML][HTML] GLP-1a: going beyond traditional use

LF Laurindo, SM Barbalho, EL Guiguer… - International Journal of …, 2022 - mdpi.com
Glucagon-like peptide-1 (GLP-1) is a human incretin hormone derived from the proglucagon
molecule. GLP-1 receptor agonists are frequently used to treat type 2 diabetes mellitus and …

Molecular mechanisms of semaglutide and liraglutide as a therapeutic option for obesity

R Tamayo-Trujillo, VA Ruiz-Pozo… - Frontiers in …, 2024 - frontiersin.org
Obesity, a chronic global health problem, is associated with an increase in various
comorbidities, such as cardiovascular disease, type 2 diabetes mellitus, hypertension, and …

A review and meta-analysis of the safety and efficacy of using glucagon-like peptide-1 receptor agonists

EH Hu, ML Tsai, Y Lin, TS Chou, TH Chen - Medicina, 2024 - mdpi.com
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been used to reduce glucose
levels in patients with type 2 diabetes mellitus since 2005. This meta-analysis discusses the …

Fecal fermentation and high-fat diet-induced obesity mouse model confirmed exopolysaccharide from Weissella cibaria PFY06 can ameliorate obesity by regulating …

Y **e, F Pei, Y Liu, Z Liu, X Chen, D Xue - Carbohydrate Polymers, 2023 - Elsevier
Obesity associated with diet and intestinal dysbiosis is a worldwide public health crisis, and
exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) have prebiotic potential to …

Diabetes-Alzheimer's connection in older age: SGLT2 inhibitors as promising modulators of disease pathways

F Mancinetti, D Xenos, M De Fano, A Mazzieri… - Ageing Research …, 2023 - Elsevier
Late-onset Alzheimer's disease (LOAD) is the most frequent cause of dementia in older
persons. Subjects affected by type 2 diabetes mellitus (T2DM) are at higher risk of vascular …

Signatures of metabolic diseases on spermatogenesis and testicular metabolism

DF Carrageta, SC Pereira, R Ferreira… - Nature Reviews …, 2024 - nature.com
Diets leading to caloric overload are linked to metabolic disorders and reproductive function
impairment. Metabolic and hormonal abnormalities stand out as defining features of …