Risk of community-acquired pneumonia with outpatient proton-pump inhibitor therapy: a systematic review and meta-analysis
Background Proton-pump inhibitors (PPIs) are among the most frequently prescribed
medications. Community-acquired pneumonia (CAP) is a common cause of morbidity …
medications. Community-acquired pneumonia (CAP) is a common cause of morbidity …
Block-and-lock strategies to cure HIV infection
G Vansant, A Bruggemans, J Janssens, Z Debyser - Viruses, 2020 - mdpi.com
Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
Redefining the viral reservoirs that prevent HIV-1 eradication
E Eisele, RF Siliciano - Immunity, 2012 - cell.com
This Perspective proposes definitions for key terms in the field of HIV-1 latency and
eradication. In the context of eradication, a reservoir is a cell type that allows persistence of …
eradication. In the context of eradication, a reservoir is a cell type that allows persistence of …
Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy
JA White, FR Simonetti, S Beg… - Proceedings of the …, 2022 - National Acad Sciences
In persons living with HIV-1 (PLWH) who start antiretroviral therapy (ART), plasma virus
decays in a biphasic fashion to below the detection limit. The first phase reflects the short …
decays in a biphasic fashion to below the detection limit. The first phase reflects the short …
Total HIV-1 DNA, a marker of viral reservoir dynamics with clinical implications
V Avettand-Fènoël, L Hocqueloux… - Clinical microbiology …, 2016 - Am Soc Microbiol
SUMMARY HIV-1 DNA persists in infected cells despite combined antiretroviral therapy
(cART), forming viral reservoirs. Recent trials of strategies targeting latent HIV reservoirs …
(cART), forming viral reservoirs. Recent trials of strategies targeting latent HIV reservoirs …
In vivo dynamics of the latent reservoir for HIV-1: new insights and implications for cure
JD Siliciano, RF Siliciano - Annual Review of Pathology …, 2022 - annualreviews.org
Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …
Gene delivery by lentivirus vectors
The capacity to efficiently transduce nondividing cells, shuttle large genetic payloads, and
maintain stable long-term transgene expression are attributes that have brought lentiviral …
maintain stable long-term transgene expression are attributes that have brought lentiviral …
HIV-1 DNA decay dynamics in blood during more than a decade of suppressive antiretroviral therapy
GJ Besson, CM Lalama, RJ Bosch… - Clinical Infectious …, 2014 - academic.oup.com
Background. Human immunodeficiency virus type 1 (HIV-1) DNA dynamics during long-term
antiretroviral therapy (ART) are not defined. Methods. Blood mononuclear cells obtained …
antiretroviral therapy (ART) are not defined. Methods. Blood mononuclear cells obtained …
HIV-1 transcription and latency: an update
C Van Lint, S Bouchat, A Marcello - Retrovirology, 2013 - Springer
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …