Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Engineered human cardiac tissues have been utilized for various biomedical applications,
including drug testing, disease modeling, and regenerative medicine. However, the …

Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …

Organoid models of early tissue development have been produced for the intestine, brain,
kidney and other organs, but similar approaches for the heart have been lacking. Here we …

Cellular models are needed to study human development and disease in vitro, and to
screen drugs for toxicity and efficacy. Current approaches are limited in the engineering of …

Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …

Organoids are powerful models for studying tissue development, physiology, and disease.
However, current culture systems disrupt the inductive tissue-tissue interactions needed for …