Antibody responses to envelope glycoproteins in HIV-1 infection
DR Burton, JR Mascola - Nature immunology, 2015 - nature.com
Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups.
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
Binding but non-neutralizing responses are directed to epitopes that are expressed on …
[HTML][HTML] Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies
PD Kwong, JR Mascola - Immunity, 2012 - cell.com
Antibodies that neutralize diverse strains of HIV-1 develop in∼ 20% of HIV-1-infected
individuals, and isolation and structural characterization of these antibodies are revealing …
individuals, and isolation and structural characterization of these antibodies are revealing …
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
X Wu, ZY Yang, Y Li, CM Hogerkorp, WR Schief… - Science, 2010 - science.org
Cross-reactive neutralizing antibodies (NAbs) are found in the sera of many HIV-1–infected
individuals, but the virologic basis of their neutralization remains poorly understood. We …
individuals, but the virologic basis of their neutralization remains poorly understood. We …
Nonsteroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection
Identifying drugs that regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) infection and its symptoms has been a pressing area of investigation during the …
2) infection and its symptoms has been a pressing area of investigation during the …
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection
JF Salazar-Gonzalez, MG Salazar, BF Keele… - Journal of Experimental …, 2009 - rupress.org
Identification of full-length transmitted HIV-1 genomes could be instrumental in HIV-1
pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those …
pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those …
Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 …
ABSTRACT A window of opportunity for immune responses to extinguish human
immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through …
immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through …
[BOOK][B] HIV and the pathogenesis of AIDS.
JA Levy - 1994 - cabidigitallibrary.org
This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …
has been updated and expanded-now citing more than 2100 references (100 pages of the …
Global panel of HIV-1 Env reference strains for standardized assessments of vaccine-elicited neutralizing antibodies
A deCamp, P Hraber, RT Bailer, MS Seaman… - Journal of …, 2014 - Am Soc Microbiol
Standardized assessments of HIV-1 vaccine-elicited neutralizing antibody responses are
complicated by the genetic and antigenic variability of the viral envelope glycoproteins …
complicated by the genetic and antigenic variability of the viral envelope glycoproteins …
Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?
Most existing viral vaccines generate antibodies that either block initial infection or help
eradicate the virus before it can cause disease. For HIV-1, obstacles to eliciting protective …
eradicate the virus before it can cause disease. For HIV-1, obstacles to eliciting protective …
Increasing the potency and breadth of an HIV antibody by using structure-based rational design
R Diskin, JF Scheid, PM Marcovecchio, AP West Jr… - Science, 2011 - science.org
Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can
show exceptional potency and breadth. We determined structures of NIH45-46, a more …
show exceptional potency and breadth. We determined structures of NIH45-46, a more …