Machine learning analysis of rivaroxaban solubility in mixed solvents for application in pharmaceutical crystallization

M Alqarni, A Alqarni - Scientific Reports, 2025 - nature.com
This study investigates the use of machine learning models to predict solubility of
rivaroxaban in binary solvents based on temperature (T), mass fraction (w), and solvent type …

Derisking Crystallization Process Development and Scale-Up Using a Complementary,“Quick and Dirty” Digital Design

Á Borsos, C Hámori, E Szilágyi, A Spaits… - … Process Research & …, 2024 - ACS Publications
Despite the spread of digital (model and AI-based) techniques, the industry-standard
pharmaceutical crystallization design and scale-up is still based on experiments' design …

[HTML][HTML] Limited data based kinetic modeling and optimization of propionic acid synthesis over supported Rh/C catalyst

L Balogh, J Bódis, B Szilágyi, Á Bárkányi… - Chemical Engineering …, 2025 - Elsevier
The importance and need for greener and more sustainable chemical processes and
technologies can hardly be overestimated. However, many industries still produce a …

Maximizing similarity: Using correlation coefficients to calibrate kinetic parameters in population balance models

Á Orosz, B Szilágyi - Heliyon, 2024 - cell.com
Crystallization plays a crucial role as a separation and purification technique, particularly in
the chemical and pharmaceutical industries. By adjusting process parameters, the …