Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

The buildup of plaques in atherosclerosis leads to cardiovascular events, with chronic
unresolved inflammation and overproduction of reactive oxygen species (ROS) being major …

The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted
through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein …

The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …

Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with
conventional risk factor control, significant residual risk remains. Recent evidence on non …

The phagocytosis of dying cells by macrophages, termed efferocytosis, is a tightly regulated
process that involves the sensing, binding, engulfment, and digestion of apoptotic cells …

With cardiovascular disease being the leading cause of morbidity and mortality worldwide,
effective and cost-efficient therapies to reduce cardiovascular risk are highly needed. Lipids …

Persistent inflammation within atherosclerotic plaques is a crucial factor contributing to
plaque vulnerability and rupture. It has become increasingly evident that the …