Complex chromosome rearrangements, known as chromoanagenesis, are widespread in
cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of …

Mutational processes that alter large genomic regions occur frequently in develo**
tumors. They range from simple copy number gains and losses to the shattering and …

Over 1.66 million humans (approx. 500/100 000 population rate) and over 4.2 million dogs
(approx. 5300/100 000 population rate) are diagnosed with cancer annually in the USA. The …

Chromothripsis scars the genome when localized chromosome shattering and repair occurs
in a one-off catastrophe. Outcomes of this process are detectable as massive DNA …

Improved identification of structural variants (SVs) in cancer can lead to more targeted and
effective treatment options as well as advance our basic understanding of the disease and …

Recent genome sequencing studies have identified several classes of complex genomic
rearrangements that appear to be derived from a single catastrophic event. These …

Alterations in nuclear shape are present in human diseases and ageing. A compromised
nuclear lamina is molecularly interlinked to altered chromatin functions and genomic …

The realization that cancer progression required the participation of cellular genes provided
one of several key rationales, in 1986, for embarking on the human genome project. Only …

In 2011, a novel form of genome instability was reported by Stephens et al., characterized by
tens to hundreds of locally clustered rearrangements affecting one or a few chromosome (s) …

Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one
or few chromosomes in multiple fragments and consequent random rejoining and repair …