Owing to its osteoinductive and osteoconductive properties and the presence of osteogenic
cells, freshly harvested autologous bone graft is the gold standard for skeletal reconstruction …

Segmental bone defect management is among the most demanding issues in orthopaedics
and there is a great medical need for establishing an appropriate treatment option. Tissue …

Bone tissue regeneration is a critical aspect of dental surgery, given the common occurrence
of bone resorption leading to alveolar bone defects. The aim of this paper was to conduct a …

Purpose Clinical studies in diabetic patients have demonstrated that there is a high
incidence of complications in distal tibia and ankle fracture treatments. One strategy to …

Purpose Because of significant complications related to the use of autologous bone grafts in
spinal fusion surgery, bone substitutes and growth factors such as bone morphogenetic …

The development of nanoscience, nanohybrid technology and molecular biology provide an
important strategy in the construction of novel bone scaffolds. Nanosized whitlockite (WH) …

Bone tissue has a strong intrinsic regenerative capacity, thanks to a delicate and complex
interplay of cellular and molecular processes, which tightly involve the immune system …

Over the last 40 years International Orthopaedics has published a series of articles on bone
morphogenetic proteins (BMPs) covering topics from basic research to clinical applications …

Overproduction of reactive oxygen species (ROS) results in oxidative stress, a critical factor
in the pathogenesis of steroid‐induced osteonecrosis of the femoral head (SONFH). Excess …

Recombinant human bone morphogenetic proteins (BMPs) have shown clinical success in
promoting bone healing, but they are also associated with unwanted side effects. The …