Optical map** is a widely used tool to record and visualize the electrophysiological
properties in a variety of myocardial preparations such as Langendorff‐perfused isolated …

Voltage-sensitive dyes (VSDs) are used to image electrical activity in cells and tissues with
submillisecond time resolution. Most of these fast sensors are constructed from push–pull …

Objective. Temperature plays a crucial role in influencing the spatiotemporal dynamics of the
heart. Electrical instabilities due to specific thermal conditions typically lead to early period …

Optogenetic stimulation combined with optical map** of membrane potential (Vm) and
calcium transients (CaT) is a powerful electrophysiological tool. We developed a novel …

From the studies of Gordon Moe in the 1960s, functional reentry has been investigated as a
mechanism for tachycardia and fibrillation; however, it was not until 1990 that optical …

Electrical activity plays a key role in physiology, in particular for signaling and coordination.
Cellular electrophysiology is often studied with micropipette-based techniques such as …

Background: The heart's mechanical state feeds back to its electrical activity, potentially
contributing to arrhythmias. Mechano-arrhythmogenesis has been mechanistically …

Cardiac electrical dynamics show complex space-time instabilities, like period-doubling
bifurcation and beat-to-beat alternans, known to occur as pro-arrhythmic phenomena and …

Electric instabilities in cardiac dynamics, arising in the form of action potential duration
alternans in time and space, are well-established precursors of arrhythmias and ventricular …

Dual voltage-calcium fluorescence optical recordings are increasingly appealing to
characterize complex spa-tiotemporal cardiac dynamics within ex-vivo whole-heart ex …