Computational models in cardiology
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources
Key points Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture
patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of …
patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of …
[HTML][HTML] In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment
Human-based computational modelling and simulation are powerful tools to accelerate the
mechanistic understanding of cardiac patho-physiology, and to develop and evaluate …
mechanistic understanding of cardiac patho-physiology, and to develop and evaluate …
Engineering approaches for cardiac organoid formation and their characterization
Cardiac organoids are 3-dimensional (3D) structures composed of tissue or niche-specific
cells, obtained from diverse sources, encapsulated in either a naturally derived or synthetic …
cells, obtained from diverse sources, encapsulated in either a naturally derived or synthetic …
Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
M Paci, RP Pölönen, D Cori, K Penttinen… - Frontiers in …, 2018 - frontiersin.org
The growing importance of human induced pluripotent stem cell-derived cardiomyoyctes
(hiPSC-CMs), as patient-specific and disease-specific models for studying cellular cardiac …
(hiPSC-CMs), as patient-specific and disease-specific models for studying cellular cardiac …
Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments
Mathematical models of ion channels, which constitute indispensable components of action
potential models, are commonly constructed by fitting to whole-cell patch-clamp data. In a …
potential models, are commonly constructed by fitting to whole-cell patch-clamp data. In a …
Considering discrepancy when calibrating a mechanistic electrophysiology model
Uncertainty quantification (UQ) is a vital step in using mathematical models and simulations
to take decisions. The field of cardiac simulation has begun to explore and adopt UQ …
to take decisions. The field of cardiac simulation has begun to explore and adopt UQ …
Advances in induced pluripotent stem cell‐derived cardiac myocytes: technological breakthroughs, key discoveries and new applications
A transformation is underway in precision and patient‐specific medicine. Rapid progress
has been enabled by multiple new technologies including induced pluripotent stem cell …
has been enabled by multiple new technologies including induced pluripotent stem cell …
Four ways to fit an ion channel model
Mathematical models of ionic currents are used to study the electrophysiology of the heart,
brain, gut, and several other organs. Increasingly, these models are being used predictively …
brain, gut, and several other organs. Increasingly, these models are being used predictively …