Sex differences in cognitive impairment and Alzheimer's disease

R Li, M Singh - Frontiers in neuroendocrinology, 2014 - Elsevier
Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's
disease between the men and women at later age. However it is important to know that sex …

Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury

EB Engler-Chiurazzi, CM Brown, JM Povroznik… - Progress in …, 2017 - Elsevier
There is ample empirical evidence to support the notion that the biological impacts of
estrogen extend beyond the gonads to other bodily systems, including the brain and …

Sex differences in risk factors for vascular contributions to cognitive impairment & dementia

OJ Gannon, LS Robison, AJ Custozzo… - Neurochemistry …, 2019 - Elsevier
Vascular contributions to cognitive impairment and dementia (VCID) is the second most
common cause of dementia. While males overall appear to be at a slightly higher risk for …

Sex differences in ischaemic stroke: potential cellular mechanisms

A Chauhan, H Moser, LD McCullough - Clinical science, 2017 - portlandpress.com
Stroke remains a leading cause of mortality and disability worldwide. More women than men
have strokes each year, in part because women live longer. Women have poorer functional …

The role of Sirt1 in ischemic stroke: pathogenesis and therapeutic strategies

JF Zhang, YL Zhang, YC Wu - Frontiers in neuroscience, 2018 - frontiersin.org
Silent mating type information regulation 2 homolog 1 (Sirt1), a nicotine adenine
dinucleotide (NAD+)-dependent enzyme, is well-known in playing a part in longevity …

SIRT 1‐dependent AMPK pathway in the protection of estrogen against ischemic brain injury

JM Guo, H Shu, L Wang, JJ Xu, XC Niu… - CNS neuroscience & …, 2017 - Wiley Online Library
Aims Stroke is a major cause of mortality and disability, especially for postmenopausal
women. In view of the protective action of estrogen, hormone therapy remains the only …

Window of opportunity: estrogen as a treatment for ischemic stroke

R Liu, SH Yang - Brain research, 2013 - Elsevier
The neuroprotection research in the last 2 decades has witnessed a growing interest in the
functions of estrogens as neuroprotectants against neurodegenerative diseases including …

Involvement of baroreflex deficiency in the age-related loss of estrogen efficacy against cerebral ischemia

L Wang, J Wang, Q Shan, H Shu… - Frontiers in Aging …, 2023 - frontiersin.org
For post-menopausal women, stroke is complicated by the variable effects of estrogen
therapy and the age-related therapeutic consequences involved. Estrogen therapy has been …

Oestrogens as M odulators of N euronal Si gnalosomes and B rain L ipid H omeostasis R elated to P rotection A gainst N eurodegeneration

R Marin, V Casañas, JA Pérez, N Fabelo… - Journal of …, 2013 - Wiley Online Library
Oestrogens trigger several pathways at the plasma membrane that exert beneficial actions
against neurodegenerative diseases, such as A lzheimer's disease and Parkinson's …

A rich-club organization in brain ischemia protein interaction network

A Alawieh, Z Sabra, M Sabra, S Tomlinson… - Scientific reports, 2015 - nature.com
Ischemic stroke involves multiple pathophysiological mechanisms with complex interactions.
Efforts to decipher those mechanisms and understand the evolution of cerebral injury is key …