Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

Despite decades of laboratory and clinical research, Alzheimer's disease (AD) is still the
leading cause of dementia in adults and there are no curative therapies currently available …

Transplanted neurons derived from stem cells have been proposed to improve function in
animal models of human disease by various mechanisms such as neuronal replacement …

Induced pluripotent stem cells (iPSCs) are becoming an important source of pre-clinical
models for research focusing on neurodegeneration. They offer the possibility for better …

Neurogenesis is a key mechanism of brain development and plasticity, which is impaired in
chronic neurodegeneration, including Parkinson's disease. The accumulation of aberrant α …

Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control
of specific neuronal populations in the brain of experimental animals, including mammals …

Neuronal loss and axonal demyelination underlie long-term functional impairments in
patients affected by brain disorders such as ischemic stroke. Stem cell-based approaches …

Pluripotent stem cells (embryonic stem cells, ESCs, and induced pluripotent stem cells,
iPSCs) have the capacity to generate neural progenitors that are intrinsically patterned to …

Organotypic hippocampal slice cultures (OHSCs) have been used as a powerful ex vivo
model for decades. They have been used successfully in studies of neuronal death …

Epilepsy is among the most common neurological disorders, affecting approximately 50
million people worldwide. Importantly, epilepsy is genetically and etiologically …