Complement in neurological disorders and emerging complement-targeted therapeutics

MC Dalakas, H Alexopoulos, PJ Spaeth - Nature Reviews Neurology, 2020 - nature.com
The complement system consists of a network of plasma and membrane proteins that
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …

Autoantibodies in chronic inflammatory neuropathies: diagnostic and therapeutic implications

L Querol, J Devaux, R Rojas-Garcia, I Illa - Nature Reviews Neurology, 2017 - nature.com
The chronic inflammatory neuropathies (CINs) are rare, very disabling autoimmune
disorders that generally respond well to immune therapies such as intravenous …

Microglia innately develop within cerebral organoids

PR Ormel, R Vieira de Sá, EJ Van Bodegraven… - Nature …, 2018 - nature.com
Cerebral organoids are 3D stem cell-derived models that can be utilized to study the human
brain. The current consensus is that cerebral organoids consist of cells derived from the …

Immune-mediated neuropathies

BC Kieseier, EK Mathey, C Sommer… - Nature reviews Disease …, 2018 - nature.com
Since the discovery of an acute monophasic paralysis, later coined Guillain–Barré
syndrome, almost 100 years ago, and the discovery of chronic, steroid-responsive …

Advances and challenges in modeling inherited peripheral neuropathies using iPSCs

J Van Lent, R Prior, G Pérez Siles, AN Cutrupi… - … & molecular medicine, 2024 - nature.com
Inherited peripheral neuropathies (IPNs) are a group of diseases associated with mutations
in various genes with fundamental roles in the development and function of peripheral …

Characterization of HIV-1 infection in microglia-containing human cerebral organoids

SBH Gumbs, A Berdenis van Berlekom, R Kübler… - Viruses, 2022 - mdpi.com
The achievement of an HIV cure is dependent on the eradication or permanent silencing of
HIV-latent viral reservoirs, including the understudied central nervous system (CNS) …

Transcriptomic and morphological maturation of human astrocytes in cerebral organoids

M Verkerke, A Berdenis van Berlekom, V Donega… - Glia, 2024 - Wiley Online Library
Cerebral organoids (CerOrgs) derived from human induced pluripotent stem cells (iPSCs)
are a valuable tool to study human astrocytes and their interaction with neurons and …

[HTML][HTML] Therapeutic monoclonal antibody therapies in chronic autoimmune demyelinating neuropathies

C Briani, A Visentin - Neurotherapeutics, 2022 - Elsevier
Autoimmune diseases of the peripheral nervous system have so far been treated mainly with
exogenous high-dose intravenous immunoglobulins (IVIg), that act through several …

Classical complement pathway inhibition in a “Human‐On‐A‐Chip” model of autoimmune demyelinating neuropathies

JW Rumsey, C Lorance, M Jackson… - Advanced …, 2022 - Wiley Online Library
Chronic autoimmune demyelinating neuropathies are a group of rare neuromuscular
disorders with complex, poorly characterized etiology. Here the authors describe a …

Multifocal motor neuropathy: controversies and priorities

WZ Yeh, PJ Dyck, LH Van Den Berg… - Journal of Neurology …, 2020 - jnnp.bmj.com
Despite 30 years of research there are still significant unknowns and controversies
associated with multifocal motor neuropathy (MMN) including disease pathophysiology …