Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting
The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …
Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications
Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …
injury in many tissues. Although the extracellular matrix deposition appears unstructured …
A water‐soluble AIEgen for noninvasive diagnosis of kidney fibrosis via SWIR fluorescence and photoacoustic imaging
D Yan, T Li, Y Yang, N Niu, D Wang, J Ge… - Advanced …, 2022 - Wiley Online Library
Early diagnosis of renal fibrosis is crucially significant on account of its worldwide prevalent
tendency. Optical imaging in the near‐infrared window has been recognized as an …
tendency. Optical imaging in the near‐infrared window has been recognized as an …
Cellular and molecular mechanisms of kidney fibrosis
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …
injury or maladaptive repair. It is considered as the underlying pathological process of …
Extracellular matrix in kidney fibrosis: more than just a scaffold
Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …
Location, location, location: how the tissue microenvironment affects inflammation in RA
Current treatments for rheumatoid arthritis (RA) do not work well for a large proportion of
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …
Kidney fibrosis: Emerging diagnostic and therapeutic strategies
An increasing number of patients worldwide suffers from chronic kidney disease (CKD).
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …
Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer
Organ fibrosis is characterized by the accumulation of disorganized and stiff extracellular
matrix (ECM) and represents the final stage of several life-threatening diseases. The …
matrix (ECM) and represents the final stage of several life-threatening diseases. The …
Recent advances in medical image processing for the evaluation of chronic kidney disease
Assessment of renal function and structure accurately remains essential in the diagnosis
and prognosis of Chronic Kidney Disease (CKD). Advanced imaging, including Magnetic …
and prognosis of Chronic Kidney Disease (CKD). Advanced imaging, including Magnetic …
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF‐β1/Smad3 and TGF‐β1/p38 MAPK Pathways
N Liu, J Feng, X Lu, Z Yao, Q Liu, Y Lv… - Mediators of …, 2019 - Wiley Online Library
Objective. Liver fibrosis is a consequence of wound‐healing responses to chronic liver insult
and may progress to liver cirrhosis if not controlled. This study investigated the protection …
and may progress to liver cirrhosis if not controlled. This study investigated the protection …