Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and agonistic antibodies
against TRAIL death receptors (DR) kill tumor cells while causing virtually no damage to …

Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a member of the
TNF superfamily that can lead to the induction of apoptosis in tumor or infected cells …

Background In cancer research, the association between a gene and clinical outcome
suggests the underlying etiology of the disease and consequently can motivate further …

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and
pathological conditions. Resistance to apoptosis is a hallmark of virtually all malignancies …

OBJECTIVES: Chemotherapy is the preferred therapeutic approach for the therapy of
advanced ovarian cancer, but a successful long-term treatment is prevented by the …

The TGFβ cytokine plays dichotomous roles during tumor progression. In normal and
premalignant cancer cells, the TGFβ signaling pathway inhibits proliferation and promotes …

The sine oculis homeobox (SIX) protein family is a group of evolutionarily conserved
transcription factors that are found in diverse organisms that range from flatworms to …

Inappropriate activation of developmental pathways is a well-recognized tumor-promoting
mechanism. Here we show that overexpression of the homeoprotein Six1, normally a …

SIX1 interacts with EYA to form a bipartite transcription factor essential for mammalian
development. Loss of function of this complex causes branchio-oto-renal (BOR) syndrome …

Ewing sarcoma (ES), which is characterized by the presence of oncogenic fusion proteins
such as EWS/FLI1, is an aggressive pediatric malignancy with a high rate of early …