The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

DNA methylation is a well-studied epigenetic modification that has key roles in regulating
gene expression, maintaining genome integrity, and determining cell fate. Precisely how …

BACKGROUND Transcriptome sequencing (RNA-seq) improves diagnostic rates in
individuals with suspected Mendelian conditions to varying degrees, primarily by directing …

Osteoarthritis (OA) is one of the most common joint diseases, there are no effective disease-
modifying drugs, and the pathological mechanisms of OA need further investigation. Here …

Nuclear receptor-binding SET domain 2 (NSD2) is a histone lysine methyltransferase
(HKMTase), which is mainly responsible for the di-methylation of lysine residues on …

Purpose Despite a few recent reports of patients harboring truncating variants in NSD2, a
gene considered critical for the Wolf–Hirschhorn syndrome (WHS) phenotype, the clinical …

Background Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential
epigenetic component for the faithful regulation of gene expression. Despite its importance …

Senescent cells may possess the intrinsic programs of metabolic and epigenomic
remodeling, but the molecular mechanism remains to be clarified. Using an RNAi‐based …

Wolf–Hirschhorn syndrome (WHS), a rare disorder determined by distal 4p deletion, is
characterized by a pre and postnatal growth retardation, hypotonia, intellectual disability …

Brain size is controlled by several factors during neuronal development, including neural
progenitor proliferation, neuronal arborization, gliogenesis, cell death, and synaptogenesis …