Technological advances in imaging techniques and biometric data acquisition have enabled
us to apply methods of network science to study the morphology and structural design of …

In recent decades, cementless implants have been widely used in clinical practice to replace
missing organs, to replace damaged or missing bone tissue or to restore joint functionality …

Diabetic osteoporosis (DOP) is the leading complication continuously threatening the bone
health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability …

Closed circulatory systems underlie the function of vertebrate organs, but in long bones their
structure is unclear although they constitute the exit route for bone marrow (BM) leukocytes …

Autophagy is an evolutionarily conserved intracellular process, in which domestic cellular
components are selectively digested for the recycling of nutrients and energy. This process …

Abstract Purpose of Review The bone is able to adapt its structure to mechanical signals via
the bone remodeling process governed by mechanosensitive osteocytes. With aging, an …

Vital osteocytes have been well known to function as an important orchestrator in the
preservation of robustness and fidelity of the bone remodeling process. Nevertheless, some …

Skeletal fragility in the elderly does not simply result from a loss of bone mass. However, the
mechanisms underlying the concurrent decline in bone mass, quality, and …

Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar
bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar …

Bone is a mineralized and elastic connective tissue that provides fundamental functions in
the human body, including mechanical support to the muscles and joints, protection of vital …