Dopamine: functions, signaling, and association with neurological diseases

MO Klein, DS Battagello, AR Cardoso… - Cellular and molecular …, 2019 - Springer
The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …

Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases

L Wang, J Li, L Di - Medicinal research reviews, 2022 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

More than a marker: potential pathogenic functions of MAP2

RA DeGiosio, MJ Grubisha, ML MacDonald… - Frontiers in molecular …, 2022 - frontiersin.org
Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

Trace amines and their receptors

RR Gainetdinov, MC Hoener, MD Berry - Pharmacological reviews, 2018 - Elsevier
Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …

β− Arrestins: structure, function, physiology, and pharmacological perspectives

J Wess, AB Oteng, O Rivera-Gonzalez… - Pharmacological …, 2023 - Elsevier
The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …

Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases

E Beurel, SF Grieco, RS Jope - Pharmacology & therapeutics, 2015 - Elsevier
Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …

Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders

EF Halff, G Rutigliano, A Garcia-Hidalgo… - Trends in …, 2023 - cell.com
Schizophrenia remains a major health burden, highlighting the need for new treatment
approaches. We consider the potential for targeting the trace amine (TA) system. We first …

Fish pigmentation and coloration: Molecular mechanisms and aquaculture perspectives

M Luo, G Lu, H Yin, L Wang, M Atuganile… - Reviews in …, 2021 - Wiley Online Library
Fish coloration, evolved from selection and adaptation, is a prominent feature of remarkable
aquaculture merits. Fish possess more pigment cell types than any other vertebrates and are …

The physiology, signaling, and pharmacology of dopamine receptors

JM Beaulieu, RR Gainetdinov - Pharmacological reviews, 2011 - Elsevier
G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …

G protein–coupled receptor signaling through β-arrestin–dependent mechanisms

PY Jean-Charles, S Kaur… - Journal of cardiovascular …, 2017 - journals.lww.com
β-arrestin1 (or arrestin2) and β-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic
adaptor proteins that were originally discovered for their inhibitory role in G protein–coupled …