Autism spectrum disorders (ASDs) and related neurological disorders are associated with
mutations in many genes affecting the ratio between neuronal excitation and inhibition …

Glia are essential for brain functioning during development and in the adult brain. Here, we
discuss the various roles of both microglia and astrocytes, and their interactions during brain …

Astrocytes negatively impact neuronal development in many models of neurodevelopmental
disorders (NDs); however, how they do this, and if mechanisms are shared across disorders …

Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-
orchidism in males and premature ovarian insufficiency in female carriers. FXS is also a …

Somatosensory over-reactivity is common among patients with autism spectrum disorders
(ASDs) and is hypothesized to contribute to core ASD behaviors. However, effective …

The Morris water maze (MWM) was described 20 years ago as a device to investigate
spatial learning and memory in laboratory rats. In the meanwhile, it has become one of the …

Deficits in social interaction are important early markers for autism and related
neurodevelopmental disorders with strong genetic components. Standardized behavioral …

Autism covers a wide spectrum of disorders for which there are many views, hypotheses and
theories. Here we propose a unifying theory of autism, the Intense World Theory. The …

Many of the diverse functional consequences of activating group 1 metabotropic glutamate
receptors require translation of pre-existing mRNA near synapses. One of these …

The cerebellum is a key player in many brain functions and a major topic of neuroscience
research. However, the cerebellar nuclei (CN), the main output structures of the cerebellum …