Acute kidney injury is an increasingly common complication of hospital admission and is
associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult …

Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …

The last few years have seen the accumulation of compelling evidence that apoptosis
(programmed cell death) plays a major role in promoting resolution of the acute …

A key feature of apoptosis is that cells undergoing this programmed form of death are
recognized by phagocytes and irgested while still intact, protecting tizsues from the …

AM J RESPIR CRIT CARE MED 1999; 160: S5− S11. Elucidation of the poorly understood
mechanisms by which acute inflammation normally resolves is likely to provide new insights …

Chronic progressive kidney diseases typically are characterized by loss of differentiated
epithelial cells and activation of mesenchymal cell populations leading to renal fibrosis in …

Kidney glomerulus mesangial cells fail to develop in mice carrying targeted null mutations in
the platelet-derived growth factor (PDGF)-B or PDGF-Rβ genes. We have examined the …

Phagocyte recognition, uptake, and nonphlogistic degradation of neutrophils and other
leukocytes undergoing apoptosis promote the resolution of inflammation. This study …

Lipoxins (LX) are eicosanoids with antiinflammatory activity in glomerulonephritis (GN) and
inflammatory diseases, hypersensitivity, and ischemia reperfusion injury. It has been …

The mannose receptor (MR) has established roles in macrophage (Mφ) phagocytosis of
microorganisms and endocytic clearance of host-derived glycoproteins, and has recently …