Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

Background and objective Depression is a globally prevalent mental condition, particularly
among older adults. Previous research has identified that social networks have a buffering …

Studies of interaction effects are of great interest because they identify crucial interplay
between predictors in explaining outcomes. Previous work has considered several potential …

Genetic factors play a major role in frontotemporal dementia (FTD). The majority of FTD
cannot be genetically explained yet and it is likely that there are still FTD risk loci to be …

It is unclear whether and to what extent stress-related exposures moderate the effects of
polygenic risk scores (PRSs) on depression and anxiety. We aimed to examine such …

Background Evidence on the association between single nucleotide polymorphisms (SNPs)
in the vitamin D receptor (VDR) and depressive symptoms is inconclusive. Objectives The …

Orexins are a family of neuropeptides secreted by neurons in the lateral hypothalamus (LH).
These peptides act widespreadly across the body by interacting with specific orexin …

Social relationships and genetic propensity are known to affect depression risk, but their
joint effects are poorly understood. This study examined the association of a polygenic index …

Background This study aimed to investigate the intrinsic and situational predictors of
depression under the health ecological model. Methods Two waves (2011 and 2013) of …

Background One of the most common mental illnesses worldwide and that has significant
negative effects on well-being and physical health, is depression. Many factors that affect the …