Atypical p38 signaling, activation, and implications for disease
JC Burton, W Antoniades, J Okalova, MM Roos… - International Journal of …, 2021 - mdpi.com
The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases,
regulating responses to environmental stress and inflammation. There is an ever-increasing …
regulating responses to environmental stress and inflammation. There is an ever-increasing …
Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components
X Sheng, C Zhang, J Zhao, J Xu, P Zhang, Q Ding… - Cell & Bioscience, 2024 - Springer
Microvascular destabilization is the primary cause of the inner blood-retinal barrier (iBRB)
breakdown and increased vascular leakage in diabetic retinopathy (DR). Microvascular …
breakdown and increased vascular leakage in diabetic retinopathy (DR). Microvascular …
BMP2 inhibits cell proliferation by downregulating EZH2 in gastric cancer
Z Chen, L Yuan, X Li, J Yu, Z Xu - Cell Cycle, 2022 - Taylor & Francis
Gastric cancer is among the most common gastrointestinal malignancies. Recent studies
have suggested that bone morphogenetic protein-2 (BMP2) is related to the development …
have suggested that bone morphogenetic protein-2 (BMP2) is related to the development …
Evidence of vascular involvement in myopia: a review
A Benavente-Perez - Frontiers in Medicine, 2023 - frontiersin.org
The benign public perception of myopia (nearsightedness) as a visual inconvenience masks
the severity of its sight-threatening consequences. Myopia is a significant risk factor for …
the severity of its sight-threatening consequences. Myopia is a significant risk factor for …
20 (R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2/HO-1 axis
W Li, K Li, W Chang, H Shi, W Zhang, Z Wang, W Li - Phytomedicine, 2024 - Elsevier
Background Although our previous work confirmed 20 (R)-ginsenoside Rg3 (R-Rg3), which
is an active ingredient in the Panax Ginseng CA Meyer, to have good anti-diabetic activity …
is an active ingredient in the Panax Ginseng CA Meyer, to have good anti-diabetic activity …
Trimetazidine mitigates high glucose-induced retinal endothelial dysfunction by inhibiting PI3K/Akt/mTOR pathway-mediated autophagy
Q Yang, S Li, Z Zhou, X Yang, Y Liu, K Hao, M Fu - Bioengineered, 2022 - Taylor & Francis
Trimetazidine (TMZ), as a metabolic regulator, has been widely testified to exhibit positive
therapeutic effects on various disease models, but its role in diabetic retinopathy has not …
therapeutic effects on various disease models, but its role in diabetic retinopathy has not …
Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases
Q Zhang, Y Jiang, C Deng, J Wang - Frontiers in Medicine, 2024 - frontiersin.org
In the field of eye health, the profound impact of exercise and physical activity on various
ocular diseases has become a focal point of attention. This review summarizes and …
ocular diseases has become a focal point of attention. This review summarizes and …
Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers
Background Proteins of the TGFβ family, which are largely studied as homodimers, are also
known to form heterodimers with biological activity distinct from their component …
known to form heterodimers with biological activity distinct from their component …
Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases
Y Wen, Y Zheng, S Hua, T Li, X Bi, Q Lu, M Li… - Current Allergy and …, 2025 - Springer
Purpose of review Bone morphogenetic protein 2 (BMP2) belongs to the transforming
growth factor-β (TGF-β) superfamily and plays an important role in regulating embryonic …
growth factor-β (TGF-β) superfamily and plays an important role in regulating embryonic …
Bone morphogenetic proteins and diabetic retinopathy
Bone morphogenetic proteins (BMPs) play an important role in bone formation and repair.
Recent studies underscored their essential role in the normal development of several …
Recent studies underscored their essential role in the normal development of several …