Atypical p38 signaling, activation, and implications for disease

JC Burton, W Antoniades, J Okalova, MM Roos… - International Journal of …, 2021 - mdpi.com
The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases,
regulating responses to environmental stress and inflammation. There is an ever-increasing …

Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components

X Sheng, C Zhang, J Zhao, J Xu, P Zhang, Q Ding… - Cell & Bioscience, 2024 - Springer
Microvascular destabilization is the primary cause of the inner blood-retinal barrier (iBRB)
breakdown and increased vascular leakage in diabetic retinopathy (DR). Microvascular …

BMP2 inhibits cell proliferation by downregulating EZH2 in gastric cancer

Z Chen, L Yuan, X Li, J Yu, Z Xu - Cell Cycle, 2022 - Taylor & Francis
Gastric cancer is among the most common gastrointestinal malignancies. Recent studies
have suggested that bone morphogenetic protein-2 (BMP2) is related to the development …

Evidence of vascular involvement in myopia: a review

A Benavente-Perez - Frontiers in Medicine, 2023 - frontiersin.org
The benign public perception of myopia (nearsightedness) as a visual inconvenience masks
the severity of its sight-threatening consequences. Myopia is a significant risk factor for …

20 (R)-ginsenoside Rg3 alleviates diabetic retinal injury in T2DM mice by attenuating ROS-mediated ER stress through the activation of the Nrf2/HO-1 axis

W Li, K Li, W Chang, H Shi, W Zhang, Z Wang, W Li - Phytomedicine, 2024 - Elsevier
Background Although our previous work confirmed 20 (R)-ginsenoside Rg3 (R-Rg3), which
is an active ingredient in the Panax Ginseng CA Meyer, to have good anti-diabetic activity …

Trimetazidine mitigates high glucose-induced retinal endothelial dysfunction by inhibiting PI3K/Akt/mTOR pathway-mediated autophagy

Q Yang, S Li, Z Zhou, X Yang, Y Liu, K Hao, M Fu - Bioengineered, 2022 - Taylor & Francis
Trimetazidine (TMZ), as a metabolic regulator, has been widely testified to exhibit positive
therapeutic effects on various disease models, but its role in diabetic retinopathy has not …

Effects and potential mechanisms of exercise and physical activity on eye health and ocular diseases

Q Zhang, Y Jiang, C Deng, J Wang - Frontiers in Medicine, 2024 - frontiersin.org
In the field of eye health, the profound impact of exercise and physical activity on various
ocular diseases has become a focal point of attention. This review summarizes and …

Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers

GR Gipson, K Nolan, C Kattamuri, AP Kenny… - BMC biology, 2023 - Springer
Background Proteins of the TGFβ family, which are largely studied as homodimers, are also
known to form heterodimers with biological activity distinct from their component …

Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases

Y Wen, Y Zheng, S Hua, T Li, X Bi, Q Lu, M Li… - Current Allergy and …, 2025 - Springer
Purpose of review Bone morphogenetic protein 2 (BMP2) belongs to the transforming
growth factor-β (TGF-β) superfamily and plays an important role in regulating embryonic …

Bone morphogenetic proteins and diabetic retinopathy

K Elmasry, S Habib, M Moustafa, M Al-Shabrawey - Biomolecules, 2021 - mdpi.com
Bone morphogenetic proteins (BMPs) play an important role in bone formation and repair.
Recent studies underscored their essential role in the normal development of several …