Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Autophagy contributes to the maintenance of intracellular homeostasis in most cells of
cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth …

As an important member of fluorescence nanoparticles, carbon dots (CDs) not only possess
exceptional chemical properties, including excellent biocompatibility, low toxicity and …

The blood-brain barrier (BBB) acts as the crucial physical filtration structure in the central
nervous system. Here, we investigate the role of a specific subset of astrocytes in the …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

Classically, mitochondria have largely been believed to influence the development of illness
by modulating cell metabolism and determining the rate of production of high-energy …

Type 2 diabetic cardiomyopathy features Ca 2+ signaling abnormalities, notably an altered
mitochondrial Ca 2+ handling. We here aimed to study if it might be due to a dysregulation of …

The global incidence of cardiac diseases is expected to increase in the coming years,
imposing a substantial socioeconomic burden on healthcare systems. Autophagy is a tightly …

Mitochondrial dysfunction of cardiomyocytes (CMs) has been identified as a significant
pathogenesis of early myocardial infarction (MI). However, only a few agents or strategies …

Mitochondrial damage is implicated as a major contributing factor for a number of
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …