Medulloblastoma and high-grade glioma represent the most aggressive and frequent lethal
solid tumors affecting individuals during pediatric age. During the past years, several models …

Understanding the fundamental processes of human brain development and diseases is of
great importance for our health. However, existing research models such as non-human …

Microfluidic chips are valuable tools for studying intricate cellular and cell–microenvironment
interactions. Traditional in vitro cancer models lack accuracy in mimicking the complexities …

Recent advances in cancer biology and therapeutics have underscored the importance of
preclinical models in understanding and treating cancer. Nevertheless, current models often …

Simple Summary Over the last two decades, there has been a major shift in cancer research
models. What was once dominated by genetically engineered mice models and fast-growing …

Simple Summary Induced pluripotent stem cells (iPSCs) are crucial for disease modeling
and cell-based therapy because they serve as an infinite source of specific human cell …

In vitro models of pediatric brain tumors (pBT) are instrumental for better understanding the
mechanisms contributing to oncogenesis and testing new therapies; thus, ideally, they …

A key challenge in cancer research is the meticulous development of models that faithfully
emulates the intricacies of the patient scenario, with emphasis on preserving intra-tumoral …

Glioblastoma multiforme (GBM) is a very aggressive and lethal primary brain cancer in
adults. The multifaceted nature of GBM pathogenesis, rising from complex interactions …

Brain cancers are some of the most complex diseases to treat, despite the numerous
advances science has made in cancer chemotherapy and research. One of the key …