Advancing the use of genome-wide association studies for drug repurposing
Genome-wide association studies (GWAS) have revealed important biological insights into
complex diseases, which are broadly expected to lead to the identification of new drug …
complex diseases, which are broadly expected to lead to the identification of new drug …
Drug repurposing: progress, challenges and recommendations
Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …
development, repurposing of'old'drugs to treat both common and rare diseases is …
Gene set knowledge discovery with Enrichr
Profiling samples from patients, tissues, and cells with genomics, transcriptomics,
epigenomics, proteomics, and metabolomics ultimately produces lists of genes and proteins …
epigenomics, proteomics, and metabolomics ultimately produces lists of genes and proteins …
ChEA3: transcription factor enrichment analysis by orthogonal omics integration
Identifying the transcription factors (TFs) responsible for observed changes in gene
expression is an important step in understanding gene regulatory networks. ChIP-X …
expression is an important step in understanding gene regulatory networks. ChIP-X …
The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations
The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common
Fund program that catalogs how human cells globally respond to chemical, genetic, and …
Fund program that catalogs how human cells globally respond to chemical, genetic, and …
Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis
X Zhao, L Zhang, J Wang, M Zhang, Z Song… - Journal of Translational …, 2021 - Springer
Background Systemic lupus erythematosus (SLE) is a multisystemic, chronic inflammatory
disease characterized by destructive systemic organ involvement, which could cause the …
disease characterized by destructive systemic organ involvement, which could cause the …
Connecting omics signatures and revealing biological mechanisms with iLINCS
There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …
and interfaces for integrative analyses and visualization that do not require programming …
[HTML][HTML] BioJupies: automated generation of interactive notebooks for RNA-Seq data analysis in the cloud
BioJupies is a web application that enables the automated creation, storage, and
deployment of Jupyter Notebooks containing RNA-seq data analyses. Through an intuitive …
deployment of Jupyter Notebooks containing RNA-seq data analyses. Through an intuitive …
Measuring interlayer shear stress in bilayer graphene
Monolayer two-dimensional (2D) crystals exhibit a host of intriguing properties, but the most
exciting applications may come from stacking them into multilayer structures. Interlayer and …
exciting applications may come from stacking them into multilayer structures. Interlayer and …
KEA3: improved kinase enrichment analysis via data integration
Phosphoproteomics and proteomics experiments capture a global snapshot of the cellular
signaling network, but these methods do not directly measure kinase state. Kinase …
signaling network, but these methods do not directly measure kinase state. Kinase …