Animal models of human disease: zebrafish swim into view
GJ Lieschke, PD Currie - Nature Reviews Genetics, 2007 - nature.com
Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …
Engineering and design of chimeric antigen receptors
Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …
Adult neurogenesis and brain regeneration in zebrafish
Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …
and the underlying activity of the adult neural stem cells differ vastly among species. In …
Interception of host angiogenic signalling limits mycobacterial growth
Pathogenic mycobacteria induce the formation of complex cellular aggregates called
granulomas that are the hallmark of tuberculosis,. Here we examine the development and …
granulomas that are the hallmark of tuberculosis,. Here we examine the development and …
An ancestral mycobacterial effector promotes dissemination of infection
JW Saelens, MI Sweeney, G Viswanathan, AM Xet-Mull… - Cell, 2022 - cell.com
The human pathogen Mycobacterium tuberculosis typically causes lung disease but can
also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting …
also disseminate to other tissues. We identified a M. tuberculosis (Mtb) outbreak presenting …