Despite the pre-eminence of the mouse in modelling human disease, several aspects of
murine biology limit its routine use in large-scale genetic and therapeutic screening. Many …

Transgenesis is an important tool for assessing gene function. In zebrafish, transgenesis has
suffered from three problems: the labor of building complex expression constructs using …

Optogenetic gene expression systems can control transcription with spatial and temporal
detail unequaled with traditional inducible promoter systems. However, current eukaryotic …

Repeated DNA makes up a large fraction of a typical mammalian genome, and some
repetitive elements are able to move within the genome (transposons and retrotransposons) …

The medaka fish Tol2 element is an autonomous transposon that encodes a fully functional
transposase. The transposase protein can catalyze transposition of a transposon construct …

Adult neurogenesis is a widespread trait of vertebrates; however, the degree of this ability
and the underlying activity of the adult neural stem cells differ vastly among species. In …

Pathogenic mycobacteria induce the formation of complex cellular aggregates called
granulomas that are the hallmark of tuberculosis,. Here we examine the development and …

Experimental studies on DNA transposable elements (TEs) have been limited in scale,
leading to a lack of understanding of the factors influencing transposition activity …