Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

The demand for organ transplantation and repair, coupled with a shortage of available
donors, poses an urgent clinical need for the development of innovative treatment strategies …

Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

Bioelectricity has been stated as a key factor in regulating cell activity and tissue function in
electroactive tissues. Thus, various biomedical electronic constructs have been developed …

Doppler tissue imaging (DTI) and DTI-derived strain imaging are robust physiologic tools
used for the noninvasive assessment of regional myocardial function. As a result of high …

The normal left ventricle comprises an inlet, apical trabecular, and an outlet portion although
these portions do not have discrete anatomical borders. The ventricular wall is thickest near …

There is strong support for the view that the ventricular myocardium has a laminar
organization in which myocytes are grouped into branching layers separated by cleavage …

Human pluripotent stem cells (hPSCs) offer a multifaceted platform to study cardiac
developmental biology, understand disease mechanisms, and develop novel therapies …

Ventricular trabeculation and compaction are two of the many essential steps for generating
a functionally competent ventricular wall. A significant reduction in trabeculation is usually …

The architecture of the heart remains controversial despite extensive effort and recent
advances in imaging techniques. Several opposing and non-mutually compatible models …