Developmental progression is driven by specific spatiotemporal domains of gene
expression, which give rise to stereotypically patterned embryos even in the presence of …

Enormous numbers of adult blood cells are constantly regenerated throughout life from
hematopoietic stem cells through a series of progenitor stages. Accessibility, robust …

Cytotoxic T lymphocytes are effector CD8+ T cells that eradicate infected and malignant
cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse …

Nuclear processes, such as V (D) J recombination, are orchestrated by the three-
dimensional organization of chromosomes at multiple levels, including compartments and …

T and B cells share a common somatic gene rearrangement mechanism for assembling the
genes that code for their antigen receptors; they also have developmental pathways with …

The B cell lineage of the hematopoietic system is responsible for the generation of high-
affinity antibodies, which provide humoral immunity for protection against foreign pathogens …

Immunoglobulin heavy chain (IgH) variable region exons are assembled from VH, D and JH
gene segments in develo** B lymphocytes. Within the 2.7-megabase mouse Igh locus, V …

Numerous transcriptional regulators of neurogenesis have been identified in the develo**
and adult brain, but how neurogenic fate is programmed at the epigenetic level remains …

The transcription factors EBF1 and Pax5 have been linked to activation of the B cell lineage
program and irreversible loss of alternative lineage potential (commitment), respectively …

Mantle cell lymphoma (MCL) is one of the most aggressive lymphoid neoplasms whose
pathogenesis is not fully understood. The neural transcription factor SOX11 is …