Abstract Several studies in Bioinformatics, Computational Biology and Systems Biology rely
on the definition of physico-chemical or mathematical models of biological systems at …

Intrinsically disordered proteins (IDPs) defy the structure–function paradigm as they fulfill
essential biological functions while lacking well‐defined secondary and tertiary structures …

Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However,
which of the myriad of detected AS events provide important biological functions is not well …

Detection of protein families in large databases is one of the principal research objectives in
structural and functional genomics. Protein family classification can significantly contribute to …

A great challenge in the proteomics and structural genomics era is to predict protein
structure and function, including identification of those proteins that are partially or wholly …

A growing number of proteins are being identified that are biologically active though
intrinsically disordered, in sharp contrast with the classic notion that proteins require a well …

Many bacteria in the environment have adapted to the presence of toxic heavy metals. Over
the last 30 years, this heavy metal tolerance was the subject of extensive research. The …

The life cycle of the parasite Plasmodium falciparum, responsible for the most deadly form of
human malaria, requires specialized protein expression for survival in the mammalian host …

Many gene defects are relatively easy to identify experimentally, but obtaining information
about the effects of sequence variations and elucidation of the detailed molecular …

Sequence analysis of the group of proteins known to be associated with hereditary diseases
allows the detection of key distinctive features shared within this group. The disease proteins …